May 12th, 2023
•Preclinical models aim to advance the knowledge of cancer biology and predict treatment efficacy. This paper describes the generation of zebrafish-based patient-derived xenografts (zPDXs) with tumor tissue fragments. The zPDXs were treated with chemotherapy, the therapeutic effect of which was assessed in terms of cell apoptosis of the transplanted tissue.
Related Videos
Labeling of Breast Cancer Patient-derived Xenografts with Traceable Reporters for Tumor Growth and Metastasis Studies
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Enhanced Viability for Ex vivo 3D Hydrogel Cultures of Patient-Derived Xenografts in a Perfused Microfluidic Platform
Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish
The Establishment and Utilization of Patient Derived Xenograft Models of Central Nervous System Metastasis
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved