JoVE Logo

Sign In

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

1.6K Views

09:09 min

August 17th, 2022

DOI :

10.3791/64095-v

August 17th, 2022


Explore More Videos

Maternal Immune Activation

Chapters in this video

0:04

Introduction

0:48

Baseline Immunoreactivity (BIR) Testing

1:56

Tail Bleed Method for Blood Collection

3:23

Weight Based Method for Mating and Gestational Embryonic Day 12.5 Injection

5:34

Investigation of Alterations in Behavior in Adult MIA and Control Offspring (Optional)

6:35

Results: Investigating Susceptibility and Resilience of Offspring to Maternal Immune Activation

8:15

Conclusion

Related Videos

article

07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

24.7K Views

article

10:08

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

2.2K Views

article

07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

17.2K Views

article

06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

3.0K Views

article

07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

18.3K Views

article

07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

11.3K Views

article

05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

10.2K Views

article

C-section of Preclinical Animal Model of Chorioamnionitis Triggered by Group B Streptococcus (GBS)

1.3K Views

article

09:24

Studying Inherited Immunity in a Caenorhabditis elegans Model of Microsporidia Infection

2.3K Views

article

08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

3.7K Views

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2025 MyJoVE Corporation. All rights reserved