Performing the Chronic Psychosocial Stress (CGS) Paradigm
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Results: Effects of Chronic Psychosocial Stress on Dams and Pups
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Conclusion
Transcript
Our protocol is significant because it represents a new paradigm for evaluating the effects of chronic stress, specifically psychosocial stress, on pregnancy outcomes. In this protocol, we expose pregnant mice to various psychosocial insults of di
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The chronic psychosocial stress (CGS) paradigm employs clinically relevant stressors during pregnancy in mice to model psychiatric disorders of mothers and infants. Here, we provide a step-by-step procedure of applying the CGS paradigm and downstream assessments to validate this model.