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Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

DOI :

10.3791/64133-v

9:41 min

January 20th, 2023

January 20th, 2023

1,063 Views

1Department of Radiology, Stanford University, 2Department of Neurology and Neurological Sciences, Stanford University

This paper details methodology for radiolabeling a human-specific anti-CD19 monoclonal antibody and how to use it to quantify B cells in the central nervous system and peripheral tissues of a mouse model of multiple sclerosis using in vivo PET imaging, ex vivo gamma counting, and autoradiography approaches.

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Imaging

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