Name: meta-analysis of the effectiveness and safety of shugan jieyu capsules for the treatment of insomnia
Uploaded: 2023-02-17T12:30:00
Description: Watch this Scientific Journal Video about Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia at JoVE.com

This work was supported by the National Nature Foundation of China (grant number 82004504) and the Chinese Medicine Administration of Sichuan Province (grant number 2021MS199).

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<ol>
	<li>Burman, D. Sleep disorders: Insomnia. Fp Essentials. 460, 22-28 (2017).</li>
	<li>Guo, L. Improving the quality of people&#39;s sleep should become a &#34;livelihood project&#34;. Xiaokang. 488 (5), 28-31 (2022).</li>
	<li>Ebben, M. R., Narizhnaya. M. Cognitive and behavioral treatment options for insomnia. Mount Sinai Journal of Medicine. 79 (4), 512-523 (2012).</li>
	<li>Sun, Y. K., et al. Effects of sedative-hypnotic pharmacotherapy on cognitive function in patients with insomnia. Chinese Journal of Neuropsychiatric Disorders. 43 (11), 701-704 (2017).</li>
	<li>Chapoutot, M. et al. Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders. International Journal of Environmental Research and Public Health. 18 (19), 10222 (2017).</li>
	<li>Atkin, T., Comai., S., Gobbi. G. Drugs for insomnia beyond benzodiazepines: Pharmacology, clinical applications, and discovery. Pharmacological Reviews. 70 (2), 197-245 (2018).</li>
	<li>Singh, A., Zhao. K. Treatment of insomnia with traditional Chinese herbal medicine. International Review of Neurobiology. 135, 97-115 (2017).</li>
	<li>Weidong, W., Tao, L., Xue, Z., Xueyu, L. V. Clininal practice guidelines of insomnia disorder. World Journal of Sleep Medicine. 3 (2), 65-79 (2016).</li>
	<li>Xu, X. W., Lv, W., Xiao, P. Q., Sun, Q., Liu, F. L. Overview of theoretical and clinical research on insomnia with Chinese medicine. World Journal of Sleep Medicine. 6 (7), 1001-1008 (2019).</li>
	<li>Hou, J. J., Lu, Y., Lv, Y., Yang, Q. Y., Xue, R. W. Clinical research progress of Chinese medicine for insomnia. Shaanxi Journal of Traditional Chinese Medicine. 40 (2), 270-272 (2019).</li>
	<li>Liang, J. H., Guan, B. H., Wu, L. M., Wang, B., Gu, W. X. Clinical research progress of traditional Chinese medicine in treating insomnia. Chinese Medicine Modern Distance Education of China. 20 (16), 198-201 (2022).</li>
	<li>Yu, Q. M., Chen, W. Y., Wang, Q., Li, M., Research progress of Chinese herbal medicines commonly used in the treatment of insomnia in Chinese medicine. Acta Chinese Medicine and Pharmacology. 50 (3), 102-107 (2022).</li>
	<li>Zhao, Q., Li, J. C., Huang, T., He, Q., Li, Y. P. Research progress of the classic prescription Tianwang Buxin Dan in the treatment of insomnia. China Pharmacy. 33 (18), 2295-2298, 2304 (2022).</li>
	<li>Expert panel of the Chinese Academy of Traditional Chinese Medicine, Psychosomatic Medicine Branch. Expert consensus on the clinical application of Shu liver relief capsules for mild to moderate depressive disorders. Journal of Beijing University of Traditional Chinese Medicine. 44 (11), 969-977 (2021).</li>
	<li>Sun, S. B. et al. A review of studies on the improvement of sleep function by Schisandra chinensis, Acanthopanax spp. and Ziziphi jujubae. Medical Food Therapy and Health. 19 (05), 196-198 (2021).</li>
	<li>Liu, H., Dai, Q. M., Zhong, L. L., Li, J. Advances in the mechanism of antidepressant effects of Guan Ye Lian Qiao. Journal of Liaoning University of Traditional Chinese Medicine. 23 (07), 40-44 (2021).</li>
	<li>Lv, Y., et al. Overview of clinical research on the treatment of depression with Shuhelian Jieyu capsule. Journal of Shanxi College of Traditional Chinese Medicin.e. 19 (5), 74-77 (2018).</li>
	<li>Liu, H. D. et al. Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation. Frontiers in Pharmacology. 13, 990996 (2022).</li>
	<li>Zhou L., Wang, M. N., Zhu, X., Cheng, H. M., Wang, Y. X. Active ingredients, pharmacological actions, and clinical applications of Acanthopanax senticosus in the central nervous system. Journal of Hunan University of Chinese Medicine. 38 (8), 961-964 (2018).</li>
	<li>Kumar, V. et al. Hypericum perforatum: Nature&#39;s mood stabilizer. Indian Journal of Experimental Biology. 38 (11), 1077-1085 (2000).</li>
	<li>Dang, J. J. et al. Study on the evidence of chronic insomnia. Chinese Journal of Basic Chinese Medicine. 28 (9), 1547-1550 (2022).</li>
	<li>Zhou, J. B., Yu, Z. J., Mai, S. Z., Lu, X. X., Liang, M. M. A randomized controlled trial of ShuMian capsule and ShuLiver relief capsule in the treatment of primary insomnia with liver qi stagnation evidence. China Medical Innovation. 16 (19), 120-123 (2019).</li>
	<li>Li, L., Zhao, Q. L. Clinical observation on the treatment of post-stroke depression with Shuhelian Xieyu capsule. Chinese Journal of Practical Neurological Disorders. 14 (9), 18-20 (2011).</li>
	<li>Xiao, J., Wang, C. J., Kong, X. F., Wang, L., Ping, H. K. Observation on the efficacy of combining liver detoxification capsule with western medicine in the treatment of perimenopausal insomnia. Journal of Modern Traditional Chinese and Western Medicine. 26 (23), 2584-2586 (2017).</li>
	<li>Xu, X. Q., Zheng, Y. Q., Xu, Q. W., Cai, Q. J. Efficacy of Shuhelian Xieyu capsule combined with risperidone in the treatment of schizophrenia with insomnia in the elderly and the effect on patients&#39; sleep quality and cognitive ability. World Journal of Sleep Medicine. 8 (6), 997-998 (2021).</li>
	<li>Zhang, Z. C., Li, S., Chen, Y., Liu, H., Zhang, Z. Progresson traditional Chinese medicine in the treatment of insomnia. Guangming Journal of Chinese Medicine. 37 (15), 2740-2743 (2022).</li>
	<li>Ni, X. et al. Traditional use of Chinese herbal medicine for insomnia and priorities setting of future clinical research. Journal of Alternative and Complementary Medicine. 25 (1), 8-15 (2019).</li>
	<li>Zhang, H., Liu, P., Wu, X., Zhang, Y., Cong, D. Effectiveness of Chinese herbal medicine for patients with primary insomnia: A PRISMA-compliant meta-analysis. Medicine. 98 (24), e15967 (2019).</li>
	<li>Patterson, P. D., et al. Evidence-based guidelines for fatigue risk management in EMS: Formulating research questions and selecting outcomes. Prehospital Emergency Care. 21 (2), 149-156 (2017).</li>
	<li>Gao, H. Diagnostic criteria for chronic insomnia disorder in the International Classification of Sleep Disorders (3rd edition). World Journal of Sleep Medicine. 5 (5), 555-557 (2018).</li>
	<li>Alprazolam is initially effective in the treatment of insomnia. InPharma. 610 (1), 9 (1987).</li>
	<li>Yin, Y., et al. Low-dose atypical antipsychotic risperidone improves the 5-year outcome in Alzheimer&#39;s disease patients with sleep disturbances. Pharmacology. 96 (3-4) 155-162 (2015).</li>
	<li>Post,&#160;G. L. et al. Estazolam treatment of insomnia in generalized anxiety disorder: A placebo-controlled study. Journal of Clinical Psychopharmacology. 11 (4), 249-253 (1991).</li>
	<li>Takaki, M. Aripiprazole as monotherapy at bedtime was effective for treatment of two cases of obsessive-compulsive disorder and insomnia. American Psychiatric Publishing. 26 (3), E64 (2014).</li>
	<li>Dolev, Z. Case series of perimenopausal women with insomnia treated with mirtazapine followed by prolonged-release melatonin add-on and monotherapy. Archives of Women&#39;s Mental Health. 14 (3), 269-273 (2011).</li>
	<li>Guthrie, K. A. et al. Effects of pharmacologic and nonpharmacologic interventions on insomnia symptoms and self-reported sleep quality in women with hot flashes: A pooled analysis of individual participant data from four MsFLASH trials. Sleep. 41 (1), zsx190 (2018).</li>
	<li>Huo, S. et al. Effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer&#39;s disease and sleep disorder: A randomized controlled trial. Brain and Behavior. 12 (2), e2488 (2022).</li>
	<li>Teaima, M. et al. Construction of sublingual trilaminated Eszopiclone fast dissolving film for the treatment of Insomnia: Formulation, characterization and in vivo clinical comparative pharmacokinetic study in healthy human subjects. PLoS One. 17 (6), e0266019 (2022).</li>
	<li>Satterlee, W. G., Faries, D. The effects of fluoxetine on symptoms of insomnia in depressed patients. Psychopharmacology Bulletin. 31 (2), 227-237 (1995).</li>
	<li>Lu, T. Y., Li, Y., Xia, P., Zhang, G. Q., Wu, D. R. Reliability and validity analysis of the Pittsburgh Sleep Quality Index. Chongqing Medicine. (3), 260-263 (2014).</li>
	<li>Diagnostic efficacy criteria for Chinese medicine illnesses by the State Administration of Traditional Chinese Medicine.31.-32. Nanjing University Press. Nanjing (1994).</li>
	<li>State Administration of Traditional Chinese Medicine. Guiding principles for clinical research of new Chinese medicines. Beijing: China Pharmaceutical Science and Technology Press. 135-139 (2002).</li>
	<li>Buysse, D. J., Reynolds, C. F. 3rd, Monk, T. H., Berman, S. R., Kupfer, D. J. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Research. 28 (2), 193-213 (1989).</li>
	<li>Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine. 6 (7), e1000097 (2010).</li>
	<li>Higgins, J. P. T., Alterman, D. G., Sterne J. A. C. Chapter 8: Assessing risk of bias in included studies. In Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0., edited by Higgins, J. P. T., Green, S. The Cochrane Collaboration. London, UK (2011).</li>
	<li>Guyatt, G. H. et al. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. The British Medical Journal. 336 (7650), 924-926 (2008).</li>
	<li>Lewis, S., Clarke, M. Forest plots: Trying to see the wood and the trees. The British Medical Journal. 322 (7300), 1479-1480 (2001).</li>
	<li>Lu, F., Lan, Y., Wang, Y., Zhou, Y. Observation of the efficacy of combining dexzopiclone with Shuhebeijiao capsule on patients with post-stroke depression with insomnia. World Journal of Sleep Medicine. 8 (09), 1495-1497 (2021).</li>
	<li>Bao, S. H., Guo, T., Zhang, K., Yuan, Z. L., Tang, L. Efficacy and mechanism of action of Shuhelian Xiezhu capsule combined with escitalopram in the treatment of depression with insomnia in the elderly. Journal of Modern Traditional Chinese and Western Medicine. 29 (30), 3385-3389 (2020).</li>
	<li>Gao, C., Zhang, J. H. Effects of combining liver detoxification capsule with western medicine on sleep and cognition in patients with liver depression and qi stagnation type insomnia. World Traditional Chinese Medicine. 13 (05), 1127-1130 (2018).</li>
	<li>Xie, N., Zhang, J. C., Wang, C. J., Liu, Y. C., Wang, L. Effect of liver detoxification treatment on the psychological and BDNF effects of perimenopausal sleep disorder (anxiety-depression type). Journal of Liaoning University of Traditional Chinese Medicine. 19 (10), 135-138 (2017).</li>
	<li>Wang, J., Hu, Y. L. Efficacy of combined Chinese and Western medicine in the treatment of insomnia in depressive disorders. Liaoning Journal of Traditional Chinese Medicine. 42 (06), 1275-1277 (2015).</li>
	<li>Lv, X., Guo, S. S. Clinical study on the treatment of post-stroke sleep disorder with Shuhelian Xieyu capsule combined with dexzopiclone. Journal of Integrated Cardiovascular and Cerebrovascular Diseases of Chinese and Western Medicine. 14 (13), 1543-1544+1568 (2016).</li>
	<li>Guo, C. H., He, X. Q., He, X. Y. Clinical observation on the treatment of insomnia in depressive disorder by combining Shuhelian Xiezhu capsule with mirtazapine. Ningxia Medical Journal. 42 (2), 179-181 (2020).</li>
	<li>Li, X. B., Wang, A. H. Analysis of the effects of combining liver detoxification capsule with western medicine on patients&#39; sleep and cognition in treating liver-depression and qi-stagnation type insomnia. Medical Theory and Practice. 32(11), 1675-1676 (2019).</li>
	<li>Chen, J., Huang, H. Y., Zhou, W. D., Liu, Q. J. Effects of liver detoxification capsule on sleep index and mental status of patients with schizophrenia combined with chronic insomnia. International Journal of Psychiatry. 44 (06), 1038-1040+1044 (2017).</li>
	<li>Zhang, M. X., Wang, L. N., Wang, X. J., Sun, Q. Q., Wang, C. H. Efficacy and safety observation of fluoxetine combined with Shuhelian Xiezhu capsule in the treatment of depression with insomnia. Journal of Xinxiang Medical College. 33 (06), 489-491, 496 (2016).</li>
	<li>Wen, X. Clinical efficacy and safety of liver detoxification capsule for schizophrenia with chronic insomnia. Journal of Clinical Rational Drug Use. 13 (12), 67-68 (2020).</li>
	<li>Chen, J. B., Jia, X. N., Quan, W., Zhang, X. H. A clinical study on the efficacy of Shuhelian Xiezhu capsule combined with escitalopram oxalate on anxiety and depression status in depressed patients. International Journal of Psychiatry., 44 (4), 635-637 (2017).</li>
	<li>Jia, J. M., Wang, H. T., Wang, Z. Q., Song, J., Zhao, S. H. Advances in the pharmacological activity of Acanthopanax spinosus. China Modern Traditional Chinese Medicine. 12 (2), 7-10+18 (2010).</li>
	<li>Huang, W., Teng, H. Y., Mao, Y. Y. Efficacy of combining liver detoxification capsule with eszopiclone in the treatment of post-stroke sleep disorder. Journal of Integrative Cardiovascular and Cerebrovascular Diseases. 16 (8), 1105-1107 (2018).</li>
	<li>Shi, M. L. et al. Meta-analysis of the effectiveness and safety of proprietary Chinese medicines in the treatment of insomnia. Chinese Journal of Traditional Chinese Medicine. 46 (20), 5403-5417 (2021).</li>
	<li>Wang, C. et al. Efficacy and safety of Shumian capsules in treating insomnia: A systematic review and meta-analysis. Medicine. 100 (50), e28194 (2021).</li>
	<li>Wang, D. et al. Discussing on the research of heterogeneity in meta-analysis.Chinese Journal of Evidence-Based Medicine. 9 (10), 1115-1118 (2009).</li>
	<li>Wang, Y. Z., Wang, J., Huang, Q. The use of subgroup analysis in drug clinical trials. Chinese Journal of Clinical Pharmacology. 28 (6), 477-480 (2012).</li>
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In the present study, a comprehensive evaluation of the effectiveness and safety of Shugan Jieyu capsules for treating insomnia was conducted, and the following results were observed. In the experimental group, using Shugan Jieyu&#160;capsules in combination with conventional Western medicine improved the overall clinical effectiveness for patients with insomnia and resulted in higher PSQI scores. Additionally, the Shugan Jieyu capsules group showed improvements in clinical outcomes, such as sleep latency, night awakenin...

Insomnia is a sleep disorder characterized by difficulty in falling asleep, difficulty in maintaining sleep, and premature or intermittent waking1, which can cause discomfort and disrupt daily functioning. According to the China Sleep Study Report (2022), over 300 million Chinese people suffered from sleep disorders in 2021, with a prevalence of insomnia among adults as high as 38.2%2.
Western medicine for insomnia treatment typically involves psychological therapies or medication3. Psychotherapies, such as simple insomnia behavior therapy and cognitive insomnia behavior therapy, aim to modify the behaviors that contribute to sleep difficulties. Sedative-hypnotic drugs, which act quickly to induce sleep, are also commonly used to treat insomnia4. However, these drugs can have toxic side effects, including respiratory depression, hypotension, and excessive sedation. The prolonged usage of these drugs can lead to dependence, resulting in significant harm and burden to the patients and their families5,6,7. In traditional Chinese medicine (TCM), insomnia is referred to as &#34;no sleep&#34; or &#34;sleeplessness&#34; and is believed to result from deficiencies in organs such as the liver, kidneys, spleen, and heart, as well as dysfunction of the heart and mind8. In the history of traditional Chinese medicine, several experts have described the mechanisms underlying insomnia; specifically, insomnia is thought to occur due to disorder of the function of the internal organs, the loss of harmony between the qi and blood, and the disorder of yin and yang, which lead to a loss of nourishment or the disturbance of the heart and mind. The basic pathological alternation of insomnia is the loss of yang and yin9. Utilizing the active ingredients of TCM and following the principles of TCM compounding for complex conditions, research10,11,12,13 has shown that TCM plays a critical role in preventing and treating insomnia. One example of a TCM treatment for insomnia is the Shugan Jieyu capsule14, which comprises Hypericumperforatum L15,16 and Acanthopanax senticosus17.
Acanthopanax senticosus18,19, a traditional Chinese herb, has been used for tonifying the middle qi and kidney and calming the mind. It has been found to effectively improve symptoms such as insomnia, excessive dreaming, and neurasthenia. Hypericum perforatum20, another traditional Chinese herb, has demonstrated antidepressant properties, with its active components potentially possessing similar antidepressant effects to tricyclic antidepressants (TCAS) and selective serotonin reuptake inhibitors (SSRIs), but with better tolerability. The combination of Hypericum perforatum and Acanthopanax senticosus has been found to regulate neurotransmitters, improve neuronal synaptic plasticity, and clinically relieve insomnia caused by mental illness; indeed, it improves the sleep quality and cognitive function of patients with liver-depression type insomnia21,22. Syndrome differentiation is a unique characteristic of TCM. The Shugan Jieyu capsule containing Hypericum perforatum and Acanthopanax senticosus is formulated to treat insomnia caused by stagnation of liver qi. It has been reported to be effective in improving the condition and safety of patients21,22. Combining these two herbs has been proven to relieve depression, calm the mind, soothe the liver, and strengthen the spleen23,24,25. However, there currently needs to be more conclusive evidence regarding the clinical effectiveness and safety of Shugan Jieyu capsules in treating insomnia.
There are various forms of Chinese herbal medicine for treating insomnia, including decoction, patent medicine, plaster, and auricular point sticking26. Previous research has examined the effect of traditional Chinese herbs on insomnia using meta-analyses. It has been found that traditional Chinese herbs significantly improve the symptoms of patients with primary insomnia, are superior to placebo, and have promising potential for research and development27,28. This study aims to evaluate the clinical effectiveness and safety of the Shugan Jieyu capsule in treating insomnia through a systematic evaluation and meta-analysis in order to provide clinical evidence and guidance for using these capsules.
The inclusion criteria for this study were defined using the population, intervention or exposure, comparison, outcome(s) (PICO) framework29. The inclusion criteria for this study were as follows: (1) randomized controlled trials (RCTs) or semi-RCTs that enrolled patients diagnosed with insomnia30; (2) studies in which the experimental group received Western medicine in combination with Shugan Jieyu capsules, while the control group received Western medicine alone (Western medicines include alprazolam tablets31, risperidone32, estazolam tablets33, aripiprazole orally disintegrating tablets34, mirtazapine35, escitalopram oxalate tablets36, eszopiclone tablets37, zopiclone tablets38, and fluoxetine dispersible tablets39); (3) studies published in Chinese or English; (4) studies in which the primary outcomes were the overall clinical effectiveness and the Pittsburgh Sleep Quality Index (PSQI)40. According to the &#34;Diagnostic Effectiveness Criteria for Chinese Medicine Evidence&#34;41 and the &#34;Guidelines for Clinical Research on New Chinese Medicines&#34;42, effective clinical outcomes are defined as patients being clinically documented as cured or showing efficacious results. The secondary outcomes identified include sleep latency, sleep duration, nighttime awakening, nightmares with excessive dreaming, daytime sleepiness, lack of energy, and sleep quality, all evaluated by the PSQI scale and the frequency of adverse events. Among these outcome measures, sleep latency, sleep duration, nighttime awakening, nightmares, daytime sleepiness, lack of energy, and sleep quality are all evaluated using the PSQI scale43.
The exclusion criteria were defined according to the PICO framework. The exclusion criteria for this study were as follows: (1) studies unrelated to insomnia; (2) duplicate published research; (3) non-randomized controlled trials; (4) non-clinical patient studies, such as preclinical and animal model studies; and (5) case reports, comments, conferences, reviews, and dissertations.

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			<td>http://www.sinomed.ac.cn/</td>
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			<td>Pubmed</td>
			<td></td>
			<td></td>
			<td>https://pubmed.ncbi.nlm.nih.gov/</td>
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			<td>VIP</td>
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			<td>http://www.cqvip.com/</td>
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meta-analysis of the effectiveness and safety of shugan jieyu capsules for the treatment of insomnia

A systematic review and meta-analysis were conducted to evaluate the clinical effectiveness and safety of Shugan Jieyu capsules for treating insomnia by searching seven databases up to February 21, 2022. The study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of the studies was assessed using the risk of bias assessment tool. This article describes in detail how to retrieve and screen the literature. The detailed steps for conducting the meta-analysis are also included in the protocol. Fourteen studies were found to be eligible, including 1,283 insomnia patients (644 with and 639 without Shugan Jieyu capsules at baseline). The meta-analysis showed a better total clinical effectiveness (odds ratio [OR]: 5.71, 95% confidence interval [CI]: 3.56 to 9.15) and a lower Pittsburgh Sleep Quality Index (PSQI) score (mean difference [MD]: &#8722;2.95, 95% CI: &#8722;4.97 to &#8722;0.93) with combined Shugan Jieyu capsules and Western medicine compared to Western medicine alone. The secondary outcomes showed that the Shugan Jieyu capsule group had significantly reduced adverse reactions and improvements in sleep duration, night awakening, nightmares with excessive dreaming, daytime sleepiness, and low energy. Further multicenter randomized trials must be encouraged to provide more concrete evidence on whether Shugan Jieyu capsules are beneficial in routine clinical practice.

Search results 
A total of 1,117 studies were identified from databases, including 204 in Chinese and 913 in English. After eliminating 392 duplicates, 725 studies remained. After reading the titles and abstracts, 31 studies remained. Eventually, 14 studies were included through reading the full texts. The search process and selection procedure are shown in Figure 1.
Study characteristics 
The characteristics of the incl...

Watch this Scientific Journal Video about Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia at JoVE.com

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

The presented protocol describes an investigation strategy and systematic review to evaluate the clinical effectiveness and safety of Shugan Jieyu capsules for treating insomnia.

A systematic review and meta-analysis were conducted to evaluate the clinical effectiveness and safety of Shugan Jieyu capsules for treating insomnia by ...

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