A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

1.6K Views

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10:55 min

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January 13th, 2023

DOI :

10.3791/64788-v

January 13th, 2023

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Eydis Oddsdottir Stenersen¹^,², Annette Olsen², Maria Melheim³, Rønnaug Solberg³^,⁴, Ingrid Dannevig⁵, Georg Schmölzer⁶^,⁷, Po-Yin Cheung⁶^,⁷, Britt Nakstad⁸^,⁹, Ola Didrik Saugstad¹⁰^,¹¹, Arild Rønnestad¹^,², Anne Lee Solevåg²

¹Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, ²Department of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, ³Department of Pediatric Research, Division of Paediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, ⁴Department of Pediatrics, Vestfold Hospital Trust, ⁵Department of Anesthesiology, Oslo University Hospital Rikshospitalet, ⁶Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, ⁷Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, ⁸Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, ⁹Department of Paediatrics and Adolescent Health, University of Botswana, ¹⁰Department of Pediatric Research, Oslo University Hospital, University of Oslo, ¹¹Department of Pediatrics, Robert H Lurie Medical Research Center, Northwestern University Chicago

Summary

This piglet model involves surgical instrumentation, asphyxiation until the cardiac arrest, resuscitation, and post-resuscitation observation. The model allows for multiple sampling per animal, and by using continuous invasive arterial blood pressure, ECG, and non-invasive cardiac output monitoring, it provides knowledge about hemodynamics and cardiac pathophysiology in perinatal asphyxia and neonatal cardiopulmonary resuscitation.

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University Of Oslo