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Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing Video (Video) | JoVE

DOI :

10.3791/64810-v

January 20th, 2023

January 20th, 2023

6,991 Views

1Department of Bioengineering, University of Pennsylvania

Here, a protocol for formulating lipid nanoparticles (LNPs) that encapsulate mRNA encoding firefly luciferase is presented. These LNPs were tested for their potency in vitro in HepG2 cells and in vivo in C57BL/6 mice.

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