Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

1.8K Views

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06:19 min

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October 20th, 2023

DOI :

10.3791/65921-v

October 20th, 2023

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Camille Goldman*¹^,²^,³^,⁴^,⁵, Natalie Suhy*¹^,²^,³^,⁴^,⁵, Jessica E. Schwarz¹^,²^,³^,⁴^,⁵, Emily Ruth Sartori¹^,²^,³^,⁴^,⁵, Rikki B. Rooklin¹^,²^,³^,⁴^,⁵, Braxton R. Schuldt¹^,²^,³^,⁴^,⁵, Louise A. Mesentier-Louro¹^,²^,³^,⁴^,⁵, Joel W. Blanchard¹^,²^,³^,⁴^,⁵

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

Summary

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Blood brain Barrier

Alzheimer s Disease

Neurodegeneration

Cerebrovascular Pathologies

Induced Pluripotent Stem Cells

Therapeutic Strategies

BBB Dysfunction

Human Brain Tissue Model

Amyloid Pathology

Personalized Therapy

Genetic Background

Cerebral Amyloid Angiopathy

Chapters in this video

0:00

Introduction

2:07

Preparing Cells to Assemble a 3D Human‐Stem‐Cell‐Derived In Vitro Blood Brain Barrier

4:11

Constructing the 3D Human‐Stem‐Cell‐Derived In Vitro Blood Brain Barrier

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