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An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

DOI :

10.3791/54592-v

December 8th, 2016

December 8th, 2016

10,837 Views

1Department of Neurology, University Hospital Münster, 2Institute of Biochemistry, University of Münster

Here, we describe an in vitro murine model of the blood-brain barrier that makes use of impedance cell spectroscopy, with a focus on the consequences on endothelial cell integrity and permeability upon interaction with activated T cells.

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In Vitro Model

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