Investigating Retinal Circuits and Molecular Localization by Pre-Embedding Immunoelectron Microscopy

In our research, we focus on retinal physiology and the disease. They need to investigate the cellular composition and the specific neurotransmitters within the retina neural circuit. The overarching goal is to explore synaptic connections and the cellular localization of neurotransmitters throughout the entire pathway.

The biggest challenge of immuno electron microscope technology is difficult in achieving a balance between structure, integrity, and positive signals. Through body immunoelectron microscopy, we provide for the first time immunochemically verified ultrastructural evidence for the labs and the review and explicit distribution, novel organic cell features, and the synaptic organization or SPIR is the most All findings suggest that the crosstalk between and the raw pathway is much more extensive than previously assumed. This neurochemically identified ultrastructural results reveal that on and off signaling may interconnect through chemical synapse in the retina's OPL.