Synthesis of Cyclic (alkyl)(amino) Carbene (Compound 1)
5:38
Synthesis of the CAAC-NHC Salt (Compound 3prot)
7:35
Synthesis of the Organic Radical CAAC-NHC-2 (Compound 4)
8:44
Results: 13C and 1H NMR Spectrum
10:10
Conclusion
副本
This protocol allows students of any level to perform the synthesis of air-sensitive compounds, for example, carbenes, or their dimers, or free radicals using a Schlenk line and cannulas for filtration. Filter cannulas allow for the isolation of v
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We present protocols for the isolation of stable heterocyclic carbenes. The synthesis of a cyclic (alkyl)(amino) carbene (CAAC) and an N-heterocyclic carbene (NHC) is demonstrated using filter cannulas and Schlenk technique. We furthermore present the synthesis of the related oxygen-sensitive, electron-rich mixed “Wanzlick dimer” and the reduced stable organic radical.
