Results: A Single Bolus Antisense Oligonucleotide (ASO) Intrathecal Injection Reduces Rat Malat1 In Vivo
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Conclusion
副本
This protocol allows the direct delivery of therapeutics into the rat's central nervous system to evaluate the pharmacokinetics, pharmacodynamics, and efficacy of novel therapeutics in rat disease models. This procedure is safe, effective, and doe
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Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.