Manuel Ascano

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling.

Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2.

The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner.

Regulation of Hedgehog signaling: a complex story.

An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling.

Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms.

Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.

A quantification of pathway components supports a novel model of Hedgehog signal transduction.

The full-length unprocessed hedgehog protein is an active signaling molecule.

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.

Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.

New insights in the mechanism of microRNA-mediated target repression.

Identification of RNA-protein interaction networks using PAR-CLIP.