National Institutes of Health, AR53579, Osteogenesis: Eine Verstärkung mit Bone Tropic Peptides National Institutes of Health, AR056422, anabole Wirkung osteogene Peptide National Institutes of Health, T32 AR050960, Muskel-Skelett-Tissue Repair and Regeneration DOD, PC051219 Nucleolin: A Novel Mediator des Prostate Cancer and Bone Marrow Endothelial Cell Adhesion Department of Defense, PC061508, Prostatakrebs Metastasen Cell-Bone Marrow Haftvermittler

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peptides from phage display library modulate gene expression in mesenchymal cells and potentiate osteogenesis in unicortical bone defects

Zwei neuartige synthetische Peptide beschleunigen Knochenbildung und können mithilfe einer Kollagen-Matrix. Das Ziel dieser Studie war es, die Auswirkungen auf die Knochenheilung in einem unikortikale Defekt-Modell zu untersuchen. Behandlung von mesenchymalen Zellen führte zu einer Zunahme der alkalischen Phosphatase-Aktivität zeigte Knöllchenbildung von den Zellen und erhöht die Expression von Genen für RUNX2, osterix, Bonesialoprotein und Osteocalcin. Ein Kollagenschwamm mit Peptid gefördert Reparatur von Knochendefekten getränkt, während die Kontrolle war weniger wirksam. Die Ergebnisse aus dieser Studie zeigten, dass mesenchymale Zellen mit Peptid in vitro behandelt Richtung Osteogenese zu unterscheiden, und, dass Peptide in vivo geliefert mit einem Kollagenschwamm die Reparatur von unikortikale Mängel zu fördern.

Watch this Scientific Journal Video about Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects at JoVE.com

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Eine Phagen-Display-Bibliothek verwendet wurde, um Peptidsequenzen, die auf Knochen zu identifizieren. Das Ziel war, die Wirkung dieser Peptide auf mesenchymale Zelldifferenzierung zu untersuchen und ihre Wirkung auf die Knochenregeneration zu bestimmen.

Peptide aus Phage Display Bibliothek Genexpression modulieren in mesenchymalen Zellen und potenzieren Osteogenesis in unikortikale Knochendefekten

Two novel synthetic peptides accelerate bone formation and can be delivered using a collagen matrix. The aim of this study was to investigate the effects ...

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17.9K Aufrufe.  University of Virginia. Eine Phagen-Display-Bibliothek verwendet wurde, um Peptidsequenzen, die auf Knochen zu identifizieren. Das Ziel war, die Wirkung dieser Peptide auf mesenchymale Zelldifferenzierung zu untersuchen und ihre Wirkung auf die Knochenregeneration zu bestimmen.