National Institutes of Health, AR53579, Osteogenesi: potenziamento con Peptidi Tropic Bone National Institutes of Health, AR056422, effetto anabolizzante di Peptidi osteogenico National Institutes of Health, T32 AR050960, riparazione e rigenerazione del tessuto muscoloscheletrico DOD, PC051219 Nucleolin: Un mediatore romanzo di cancro alla prostata e del midollo osseo endoteliale Adesione Cellulare Dipartimento della Difesa, PC061508, cancro alla prostata Metastasi Cell-Bone Marrow adesione mediatori

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La produzione di questo video è stato sponsorizzato dal New England Biolabs, Inc, che produce alcuni dei reagenti utilizzati in questo articolo.

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peptides from phage display library modulate gene expression in mesenchymal cells and potentiate osteogenesis in unicortical bone defects

Due peptidi sintetici romanzo di accelerare la formazione delle ossa e può essere consegnata usando una matrice di collagene. Lo scopo di questo studio era di indagare gli effetti sulla riparazione ossea in un modello difetto unicortical. Il trattamento di cellule mesenchimali prodotto un aumento dell&#39;attività della fosfatasi alcalina, ha mostrato la formazione di noduli da parte delle cellule, e aumentato l&#39;espressione di geni per Runx2, osterix, osso sialoprotein ed osteocalcina. Una spugna imbevuta di collagene con peptide promosso riparazione di difetti ossei, mentre il controllo è meno efficace. I risultati di questo studio hanno dimostrato che le cellule mesenchimali trattati con peptide differenziarsi in vitro verso osteogenesi, e, che i peptidi consegnato in vivo, utilizzando una spugna di collagene promuovere la riparazione di difetti unicortical.

Watch this Scientific Journal Video about Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects at JoVE.com

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Una libreria di phage display è stato utilizzato per identificare sequenze peptidiche che l&#39;osso di destinazione. L&#39;obiettivo era quello di indagare l&#39;effetto di questi peptidi sulla differenziazione delle cellule mesenchimali e di determinare il loro effetto sulla rigenerazione ossea.

Peptidi dalla libreria phage display modulare l&#39;espressione genica nelle cellule mesenchimali e potenziare Osteogenesi in difetti ossei Unicortical

Two novel synthetic peptides accelerate bone formation and can be delivered using a collagen matrix. The aim of this study was to investigate the effects ...

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17.9K Views.  University of Virginia. Una libreria di phage display è stato utilizzato per identificare sequenze peptidiche che l'osso di destinazione. L'obiettivo era quello di indagare l'effetto di questi peptidi sulla differenziazione delle cellule mesenchimali e di determinare il loro effetto sulla rigenerazione ossea.