We would like to thank the whole Service of Neuroradiology. We would like to thank Lis Prussen for her work in the library.

HINWEIS: Dieses Protokoll folgt den Richtlinien des Centre Hospitalier de Luxemburg in Luxemburg. 1. Herstellung der Diffusion Tensor Imaging für die Visual-Bahn für Neurochirurgie und Follow Up <ol style="margin-left: 40px;"><li> Führen Sie eine MRI-Scan mindestens einen Tag vor der Operation streng axial mit 32 Gradientenrichtungen und ein b0-Bild. Halten Sie in engem Kontakt mit der Neuroradiologie Einheit in jedem Augenblick. HINWEIS: Machen Sie deutlich, auf die Neuroradiologen, dass die Bilder nach der Operation sind die gleichen wie jene, die vor der Operation. </li><li> Mit einem 3-Tesla-MRT, führen Sie eine 3DT1-gewichtet und DTI-Sequenz-Scans. Führen Sie eine 3DT1-gewichtete Sequenz nach der Operation als auch. </li></ol> 2. Mit der Planungsstation <ol><li> Übertragen Sie die T2-gewichteten, 3DT1-gewichtet und DTI-Sequenz von Scandaten an digitalen Bildbearbeitung und Kommunikation in der Medizin (DICOM). Dieser Vorgang dauert bis zu 7 min. HINWEIS: Don `t Stop des Verfahrens before mit übertragen alle Sequenzen. Es ist möglich, zu stoppen und später fortsetzen je nach dem Zeitpunkt der Operation. </li><li> Öffnen Sie das chirurgische Navigationssystem-Programm. Klicken Sie auf Datei und dann auf Import DICOM. Wiederholen Sie diesen Vorgang drei Mal für alle oben genannten Sequenzen. <ol><li> Klicken Sie auf Hinzufügen, um anzuzeigen. Fügen Sie jede Sequenz getrennt. Don `t versuchen, mit Blick fortzufahren. </li></ol></li><li> Klicken Sie auf Extras. Öffnen DTI Tensor Vorbereitung. Beachten Sie ein neues Fenster in der Mitte des Bildschirms. </li><li> Führen Sie die folgenden vier Schritte. <ol><li> Führen Gradient Zuordnung als ersten Schritt. <ol><li> Ändern Sie den Wert B-1000 bis 800 s / mm ² auf der rechten unteren Ecke des Fensters. </li><li> Stellen Sie die Schwelle in der oberen rechten Bereich des Fensters. Tun Sie es manuell, indem Sie einfach eine Nummer oder schriftlich einen Cursor. 20 könnte ein akzeptabler Wert. Es ist eine persönliche Erfahrung und es ist nicht zwingend. </li></ol></li><li> Führen Gradient Registrierung als zweiten Schritt. <ol> &lt;li&gt; Klicken Sie auf die Schaltfläche Alle Auto. Dieser Vorgang dauert bis zu 5 min. </li><li> Klicken Sie auf Überprüfen alle Registrierungen. Ohne Überprüfung der Registrierung ist es nicht möglich, fortzufahren. </li></ol></li><li> Führen Koregistrierung als dritte Stufe. <ol><li> Coregister MR1 und MR2 b0 Bilder manuell. Am Ende holte alle Anmeldungen. Hinweis: Es ist möglich, diesen Schritt automatisch durchführen. Jedoch können die Ergebnisse nicht an das Ende immer zufriedenstellend. </li></ol></li><li> Führen Tensor-Berechnung als vierte und letzte Schritt, <ol><li> Stellen Sie sicher, FA / DEC / ADC auf. Wenn nicht klicken Sie auf. </li><li> Klicken Sie auf Compute. Dieses Verfahren wird nur einige Sekunden dauern. </li></ol></li></ol></li><li> Speichern Sie alle Daten und fahren Sie mit fibertracking. Ohne zu speichern alles, was nicht zu stoppen. </li></ol> 3. Fibertracking HINWEIS: Anatomische Kenntnisse der Sehbahn ist für die erfolgreiche Ergebnis sehr wichtig. <ol stYLE = &quot;margin-left: 40px;&quot;&gt; <li> Vorzubereiten, um die drei wichtigen Punkte, wo die Fasern zu durchlaufen zu finden. </li><li> Bestimmen Sie die Chiasma mit anatomischen Kenntnissen. <ol><li> Verwenden Sie eine ROI als Ausgangspunkt und lassen sich die Fasern durch zu gehen. ROIs werden durch den Arzt festgelegt. </li><li> Alternativ Segment der mutmaßliche Region. Klicken Sie Segmentierung auf der unten links und ein weiteres Fenster erscheint. Segmentiert Bereiche sind anatomisch definierten Bereichen. <ol><li> Die Region malen manuell. Blättern Sie nach oben und unten, um die ganze Chiasma gehören. Speichern Sie die Prozedur und gehen Sie zurück. </li></ol></li><li> Spur der Fasern entweder aus dem interessierenden Bereich oder dem Segmentbereich oder beides. </li><li> Die Fasern erreichen die linke Kniehöcker (LGN), die der zweite wichtige Punkt der Sehbahn ist. Der maximale Winkel war 50. Das Risiko von Fehlwege mit, wenn der Winkel ist zu hoch steigen. <ol><li> Es besteht die Möglichkeit, dem Segment LGN wie Chiasma gezeigtenund dann verfolgen, der Fasern. Nachdem segmentiert Chiasma, Track Fasern, die von der LGN und Ziel in Chiasma oder umgekehrt laufen. </li></ol></li><li> Segment der visuelle Kortex. Gehen Sie wie im Fall des Chiasma. Dies könnte einige Zeit dauern, wie 3DT1-gewichteten Bild enthält 160 Scheiben. </li><li> Verfolgen die Fasern aus dem visuellen Kortex zu der LGN. Es ist möglich, sie von der LGN dem visuellen Kortex sowie verfolgen. </li><li> Wenn der visuelle Kortex durch einen Tumor oder Ödeme drangen dann mit einem Bereich von Interesse anstelle eines segmentierten Bereich und lassen Sie dann die in Richtung der LGN laufen Fasern. HINWEIS: Wenn das Ödem ist segmentiert manchmal könnte die visuelle Kortex dann dringen dann könnte der Sehrinde nicht in der Lage, vollständig segmentiert, weil der Computer `t zwischen ihnen zu unterscheiden. That `s, warum es notwendig ist, um einen ROI setzen. </li><li> Wiederholen Sie alles, was für die andere Hemisphäre. </li><li> Beginnen Sie mit der gesunden Hemisphäre zuerst. Hinweis: Esmöglich ist, mit dem anderen zu starten, aber könnte es einfacher sein, um die Fasern der gesunden Hemisphäre erste Spur zu einer ersten Idee über die Lage zu werden. Es ist nicht zwingend, es ist nur eine Beratung ist. </li></ol></li><li> Segment der zerebrale Läsion und das Ödem. Gehen Sie wie oben in 3.2.2 erwähnt. <ol><li> Weisen Sie eine Farbe für jeden Segmentbereich oder Läsion, um besser zu unterscheiden. </li></ol></li><li> Speichern Sie die Prozedur nach jedem Schritt den Fall unvorhergesehener Ereignisse oder in einem Notfall. </li><li> Exportieren Sie die gesamte Daten lokal. Es ist möglich, sie in den Operationssaal unmittelbar exportieren, aber es isn `empfohlen. <ol><li> Drücken Sie auf Datei und dann Export 3D-Objekte. Achten Sie darauf, nur die Navigation Exam exportieren. </li><li> Don `t exportieren Hybrid Exam. </li></ol></li><li> Geben Hirn. Wählen Sie den richtigen Patienten und drücken Sie dann Stealthmerge. Wählen Sie 3DT1-gewichteten Aufnahmen als Referenz-Prüfung. </li><li> Erstellen Sie ein 3D-Modell und setzen alles. </li><li> Importieren Sie die Daten, die ichn der Betrieb Raum. </li></ol>

<ol>
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The authors declare that they have no competing financial interests.

DTI ist eine Technik, so dass der Neurochirurg an der weißen Substanz in vivo 8 visualisieren. Sehbahn ist eine dieser Bahnen. Obwohl dieses Verfahren bietet Ärzten neue Möglichkeiten hinsichtlich der Behandlung von Patienten mit Läsionen über eloquent Regionen des Gehirns wir sagen, dass einige Einschränkungen dieser Technik noch nicht existieren. Die erste und offensichtlichste Herausforderung Gehirn Verschiebung, die ein Problem in Untersuchung 4 bleibt. Nach dem Öffnen der Dura ...

Diffusions-Tensor-Bildgebung (DTI) wird verwendet, um WMT nicht-invasiv in das menschliche Gehirn 1 darzustellen. Es hat sich in den letzten zehn Jahren verwendet worden, um das Risiko während der Operation 1 beredten Bereichen des Gehirns zu schädigen verringern. DTI wurde in fünfzig Patienten, zwischen März 2012 und Januar 2014 durchgeführt, um die Sehbahn zu porträtieren. DTI könnte Erhaltung der beredte Bereiche des Gehirns während der Operation zu verbessern, indem wichtige Informationen über die anatomische Lage von der weißen Substanz. Es hat sich in die strategische Planung für die Resektion von komplexen Hirnläsionen 1 integriert. , Die Darstellung der Sehbahn bleibt jedoch eine Herausforderung, denn es gibt keinen Standard für die Parameter des DTI, die Platzierung der Samenvolumen und Interpretation der Ergebnisse 12. Verschiedene Algorithmen sind bisher 19-21 implementiert. Einige Ansätze konzentrierten sich auf deterministische Methoden 19, 22-25. Andere wurden mit probabilistischen Methoden, 26,27,29. In jüngerer Zeit Techniken mit Q-Ball Tensorfeldern, Diffusion Spectral Imaging und hohe Winkelauflösung Diffusionsbildgebung (HARDI) werden eingesetzt, um der weißen Substanz unter anderem die Sehbahn 1,13-15,18 darzustellen. Dennoch ist die erforderliche Zeit für HARDI signifikant länger mit 45 min ist die Software, die nicht im Handel erhältlich und betont wissenschaftliche Anwendungen 18. Die Vorlesungszeit für HARDI scheint länger als bei DTI 18 sein. Das vorgestellte Protokoll ist einfach möglich und kann für die tägliche Routine in neurochirurgischen Operationen, um die Morbidität zu vermeiden und die postoperative Ergebnis verwendet werden. Die zusätzliche Zeit für dieses Protokoll von weniger als 9 Minuten, die deutlich schneller als andere Protokolle 1,9,12,16 ist. In Anerkennung der Tatsache, dass viele hoch entwickelte Algorithmen haben vor kurzem die Papier schränkt entwickeltsich auf die Verwendung eines im Handel erhältlichen und FDA zugelassenen Software. Es ist jedoch zwingend zu berücksichtigen, die Grenzen dieser Technik, die oben genannt sind, zu nehmen.

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</table>

dti of the visual pathway - white matter tracts and cerebral lesions

<html> DTI ist eine Technik, die der weißen Substanz (WMT) nicht-invasiv bei gesunden und nicht gesunden Patienten mit Diffusionsmessungen identifiziert. Ähnlich wie der Sehbahn (VP), WMT sind nicht mit klassischen MRT oder intraoperativ mit Mikroskop sichtbar. DIT hilft Neurochirurgen zur Zerstörung der VP zu verhindern, während das Entfernen Läsionen neben diesem WMT. Wir haben DTI auf fünfzig Patienten vor und nach der Operation von März 2012 bis Januar 2014 durchgeführt, um zu navigieren verwendeten wir eine 3DT1-gewichtete Sequenz. Zusätzlich führten wir eine T2-gewichtete und DTI-Sequenzen. Die verwendeten Parameter waren, FOV: 200 x 200 mm, Schichtdicke: 2 mm, und die Erfassungsmatrix 96 x 96 ergibt nahezu isotropen Voxel von 2 x 2 x 2 mm. Axial MRI wurde mit einer 32 Gradientenrichtung und einer b0-Bild durchgeführt wird. Wir verwendeten Echo-Planar-Imaging (EPI) und Asset parallele Bildgebung mit einem Beschleunigungsfaktor von 2 und B-Wert von 800 s / mm ². Die Scanzeit betrug weniger als 9 min. ent &quot;&gt; Die DTI-Daten gewonnen wurden mit einer FDA-Zulassung chirurgische Navigationssystem-Programm, das eine einfache Faser-Tracking-Ansatz als Faser Zuordnung durch kontinuierliche Verfolgung (FACT) bekannt nutzt verarbeitet. Dieses beruht auf der Ausbreitung von Linien zwischen den Regionen von Interesse (basierend ROI), die von einem Arzt festgelegt wird. einem Winkel von maximal 50, FA Anfangswert von 0,10 und ADC-Stoppwert von 0,20 mm ² / s wurden die für tractography verwendeten Parameter. Es gibt einige Einschränkungen dieser Technik. Die begrenzte Erwerb Zeitrahmen erzwingt Kompromisse in der Bildqualität. Ein weiterer wichtiger Punkt nicht zu vernachlässigen ist das Gehirn Verschiebung während der Operation. Was die letztere intra-operative MRT hilfreich sein könnte. Darüber hinaus ist das Risiko von falsch-positiven oder falsch-negativen Flächen muss berücksichtigt werden, die die endgültigen Ergebnisse beeinträchtigen könnten, getroffen werden.

<html> Dieses Protokoll ermöglicht es dem Arzt, angemessen darzustellen, die große Teile der VP. Es kann mit einer kleinen Menge an Zeit, um Schäden bei Patienten mit zerebralen Läsionen neben beredten Bereichen zu verhindern verwendet werden. Postoperative Kontrollen zeigen auch gute Ergebnisse. VP ist in Figur 7 dargestellt, nachdem der Patient aus einem Glioblastom betrieben. 2 zeigt das VP nach Rezidiv eines Glioblastoms. Die Autoren erkennen die Tatsache der Schwierigkeiten, mit...

Watch this Scientific Journal Video about DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions at JoVE.com

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Diffusions-Tensor-Bildgebung (DTI) wurde durchgeführt, um zu versuchen, die wichtigsten Teile der Sehbahn darzustellen. Das Ziel war, verwenden ein von der FDA zugelassenen handelsüblichen Workstation, die für die tägliche Routine, um verwendet werden könnten, um zu versuchen, die postoperative Schädigung der Sehbahn bei den Patienten zu reduzieren.

DTI der Sehbahn - der weißen Substanz und zerebrale Läsionen

DTI is a technique that identifies white matter tracts (WMT) non-invasively in healthy and non-healthy patients using diffusion measurements. Similar to ...

dti-of-the-visual-pathway-white-matter-tracts-and-cerebral-lesions

Research

JoVE Journal

Medicine

13.9K Aufrufe.  Centre Hospitalier de Luxembourg.  Diffusions-Tensor-Bildgebung (DTI) wurde durchgeführt, um zu versuchen, die wichtigsten Teile der Sehbahn darzustellen. Das Ziel war, verwenden ein von der FDA zugelassenen handelsüblichen Workstation, die für die tägliche Routine, um verwendet werden könnten, um zu versuchen, die postoperative Schädigung der Sehbahn bei den Patienten zu reduzieren. 

Serie: DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Focal cerebral ischemia is among the most common type of stroke seen in patients. Due to the clinical significance there has been a prolonged effort to develop suitable animal models to study the events that unfold during ischemic insult. These techniques include transient or permanent, focal or global ischemia models using many different animal models, with the most common being rodents.
The permanent MCA ligation method which is also referred as pMCAo in the literature is used extensively as a focal ischemia model in rodents 1-6. This method was originally described for rats by Tamura et al. in 1981 7. In this protocol a craniotomy was used to access the MCA and the proximal regions were occluded by electrocoagulation. The infarcts involve mostly cortical and sometimes striatal regions depending on the location of the occlusion. This technique is now well established and used in many laboratories 8-13. Early use of this technique led to the definition and description of &#x201C;infarct core&#x201D; and &#x201C;penumbra&#x201D; 14-16, and it is often used to evaluate potential neuroprotective compounds 10, 12, 13, 17. Although the initial studies were performed in rats, permanent MCA ligation has been used successfully in mice with slight modifications 18-20 .
This model yields reproducible infarcts and increased post-survival rates. Approximately 80% of the ischemic strokes in humans happen in the MCA area 21 and thus this is a very relevant model for stroke studies. Currently, there is a paucity of effective treatments available to stroke patients, and thus there is a need for good models to test potential pharmacological compounds and evaluate physiological outcomes. This method can also be used for studying intracellular hypoxia response mechanisms in vivo. 
Here, we present the MCA ligation surgery in a C57/BL6 mouse. We describe the pre-surgical preparation, MCA ligation surgery and 2,3,5 Triphenyltetrazolium chloride (TTC) staining for quantification of infarct volumes.

Middle cerebral artery (MCA) ligation is a technique to study focal cerebral ischemia in animal models. In this method, the middle cerebral artery is exposed by craniotomy and ligated by cauterization. This method gives highly reproducible infarct volumes and increased post-operative survival rates compared to other methods available.

Die Anwendung des dauerhaften mittleren Hirnarterie Ligation in der Maus

Focal cerebral ischemia is among the most common type of stroke seen in patients. Due to the clinical significance there has been a prolonged effort to ...

Forschung

Medizin

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Patients suffering from homonymous hemianopia after infarction of the posterior cerebral artery (PCA) report different degrees of constraint in daily life, despite similar visual deficits. We assume this could be due to variable development of compensatory strategies such as altered visual scanning behavior. Scanning compensatory therapy (SCT) is studied as part of the visual training after infarction next to vision restoration therapy. SCT consists of learning to make larger eye movements into the blind field enlarging the visual field of search, which has been proven to be the most useful strategy1, not only in natural search tasks but also in mastering daily life activities2. Nevertheless, in clinical routine it is difficult to identify individual levels and training effects of compensatory behavior, since it requires measurement of eye movements in a head unrestrained condition. Studies demonstrated that unrestrained head movements alter the visual exploratory behavior compared to a head-restrained laboratory condition3. Martin et al.4 and Hayhoe et al.5 showed that behavior demonstrated in a laboratory setting cannot be assigned easily to a natural condition. Hence, our goal was to develop a study set-up which uncovers different compensatory oculomotor strategies quickly in a realistic testing situation: Patients are tested in the clinical environment in a driving simulator. SILAB software (Wuerzburg Institute for Traffic Sciences GmbH (WIVW)) was used to program driving scenarios of varying complexity and recording the driver's performance. The software was combined with a head mounted infrared video pupil tracker, recording head- and eye-movements (EyeSeeCam, University of Munich Hospital, Clinical Neurosciences).
The positioning of the patient in the driving simulator and the positioning, adjustment and calibration of the camera is demonstrated. Typical performances of a patient with and without compensatory strategy and a healthy control are illustrated in this pilot study. Different oculomotor behaviors (frequency and amplitude of eye- and head-movements) are evaluated very quickly during the drive itself by dynamic overlay pictures indicating where the subjects gaze is located on the screen, and by analyzing the data. Compensatory gaze behavior in a patient leads to a driving performance comparable to a healthy control, while the performance of a patient without compensatory behavior is significantly worse. The data of eye- and head-movement-behavior as well as driving performance are discussed with respect to different oculomotor strategies and in a broader context with respect to possible training effects throughout the testing session and implications on rehabilitation potential.

Patients with visual deficits after stroke report about different constraints in daily life most likely due to variable compensatory strategies, which are difficult to differentiate in clinical routine. We present a clinical set-up which allows measurement of different compensatory head- and eye-movement-strategies and evaluating their effects on driving performance.

Fahrsimulation in der Klinik: Testen von Visual Exploratory Behavior in Aktivitäten des täglichen Lebens bei Patienten mit Gesichtsfeldstörungen

Patients suffering from homonymous hemianopia after infarction of the posterior cerebral artery (PCA) report different degrees of constraint in daily ...

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

The translational potential of pre-clinical stroke research depends on the accuracy of experimental modeling. Cerebral perfusion monitoring in animal models of acute ischemic stroke allows to confirm successful arterial occlusion and exclude subarachnoid hemorrhage. Cerebral perfusion monitoring can also be used to study intracranial collateral circulation, which is emerging as a powerful determinant of stroke outcome and a possible therapeutic target. Despite a recognized role of Laser Doppler perfusion monitoring as part of the current guidelines for experimental cerebral ischemia, a number of technical difficulties exist that limit its widespread use. One of the major issues is obtaining a secure and prolonged attachment of a deep-penetration Laser Doppler probe to the animal skull. In this video, we show our optimized system for cerebral perfusion monitoring during transient middle cerebral artery occlusion by intraluminal filament in the rat. We developed in-house a simple method to obtain a custom made holder for twin-fibre (deep-penetration) Laser Doppler probes, which allow multi-site monitoring if needed. A continuous and prolonged monitoring of cerebral perfusion could easily be obtained over the intact skull.

Cerebral perfusion monitoring has been demonstrated to improve accuracy in ischemic stroke models. Technical difficulties often limit the use of this essential tool for cerebrovascular research. In this video, an optimized system is shown to obtain a single or multi-site hemodynamic monitoring during intraluminal middle cerebral artery occlusion in rats.

Optimierte System for Cerebral Perfusion Überwachung im Rat Stroke Modell Intraluminal Middle Cerebral Artery Occlusion

The translational potential of pre-clinical stroke research depends on the accuracy of experimental modeling. Cerebral perfusion monitoring in animal ...

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Stroke is a leading cause of death, disability, and socioeconomic loss worldwide. The majority of all strokes result from an interruption in blood flow (ischemia) 1. Middle cerebral artery (MCA) delivers a great majority of blood to the lateral surface of the cortex 2, is the most common site of human stroke 3, and ischemia within its territory can result in extensive dysfunction or death 1,4,5. Survivors of ischemic stroke often suffer loss or disruption of motor capabilities, sensory deficits, and infarct. In an effort to capture these key characteristics of stroke, and thereby develop effective treatment, a great deal of emphasis is placed upon animal models of ischemia in MCA.
Here we present a method of permanently occluding a cortical surface blood vessel. We will present this method using an example of a relevant vessel occlusion that models the most common type, location, and outcome of human stroke, permanent middle cerebral artery occlusion (pMCAO). In this model, we surgically expose MCA in the adult rat and subsequently occlude via double ligature and transection of the vessel. This pMCAO blocks the proximal cortical branch of MCA, causing ischemia in all of MCA cortical territory, a large portion of the cortex. This method of occlusion can also be used to occlude more distal portions of cortical vessels in order to achieve more focal ischemia targeting a smaller region of cortex. The primary disadvantages of pMCAO are that the surgical procedure is somewhat invasive as a small craniotomy is required to access MCA, though this results in minimal tissue damage. The primary advantages of this model, however, are: the site of occlusion is well defined, the degree of blood flow reduction is consistent, functional and neurological impairment occurs rapidly, infarct size is consistent, and the high rate of survival allows for long-term chronic assessment.

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.

Permanent Cerebral Gefäßverschluss<em&gt; Über</em&gt; Double Blattschraube und Durchtrennung

Stroke is a leading cause of death, disability, and socioeconomic loss worldwide. The majority of all strokes result from an interruption in blood flow ...

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

The generation and analysis of vascular lesions in appropriate animal models is a cornerstone of research into cardiovascular disease, generating important information on the pathogenesis of lesion formation and the action of novel therapies. Use of atherosclerosis-prone mice, surgical methods of lesion induction, and dietary modification has dramatically improved understanding of the mechanisms that contribute to disease development and the potential of new treatments.
Classically, analysis of lesions is performed ex vivo using 2-dimensional histological techniques. This article describes application of optical projection tomography (OPT) to 3-dimensional quantitation of arterial lesions. As this technique is non-destructive, it can be used as an adjunct to standard histological and immunohistochemical analyses.
Neointimal lesions were induced by wire-insertion or ligation of the mouse femoral artery whilst atherosclerotic lesions were generated by administration of an atherogenic diet to apoE-deficient mice.
Lesions were examined using OPT imaging of autofluorescent emission followed by complementary histological and immunohistochemical analysis. OPT clearly distinguished lesions from the underlying vascular wall. Lesion size was calculated in 2-dimensional sections using planimetry, enabling calculation of lesion volume and maximal cross-sectional area. Data generated using OPT were consistent with measurements obtained using histology, confirming the accuracy of the technique and its potential as a complement (rather than alternative) to traditional methods of analysis.
This work demonstrates the potential of OPT for imaging atherosclerotic and neointimal lesions. It provides a rapid, much needed ex vivo technique for the routine 3-dimensional quantification of vascular remodelling.

Ex vivo analysis of arterial lesions from animal models of cardiovascular disease classically relies on histological and immunohistochemical techniques. These provide 2-dimensional measurements in 3-dimensional lesions. This manuscript describes the generation of arterial lesions for quantitative analysis in 3-dimensions using optical projection tomography.

Generation und 3-Dimensional Quantifizierung der arterielle Läsionen in Mäuse mit optischen Projektionstomographie

The generation and analysis of vascular lesions in appropriate animal models is a cornerstone of research into cardiovascular disease, generating ...

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Atherosclerosis is a disease of the large arteries and a major underlying cause of myocardial infarction and stroke. Several different mouse models have been developed to facilitate the study of the molecular and cellular pathophysiology of this disease. In this manuscript we describe specific techniques for the quantification and characterization of atherosclerotic lesions in the murine aortic sinus and ascending aorta. The advantage of this procedure is that it provides an accurate measurement of the cross-sectional area and total volume of the lesion, which can be used to compare atherosclerotic progression across different treatment groups. This is possible through the use of the valve leaflets as an anatomical landmark, together with careful adjustment of the sectioning angle. We also describe basic staining methods that can be used to begin to characterize atherosclerotic progression. These can be further modified to investigate antigens of specific interest to the researcher. The described techniques are generally applicable to a wide variety of existing and newly created dietary and genetically-induced models of atherogenesis.

We describe procedures to quantify and characterize atherosclerotic lesions in mouse models using precision sectioning of the aortic sinus and ascending aorta combined with histochemical and immunohistochemical analysis.

Atherosclerosis is a disease of the large arteries and a major underlying cause of myocardial infarction and stroke. Several different mouse models have ...

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

In order to follow optic neuritis patients and evaluate the effectiveness of their treatment, a handy, accurate and quantifiable tool is required to assess changes in myelination at the central nervous system (CNS). However, standard measurements, including routine visual tests and MRI scans, are not sensitive enough for this purpose. We present two visual tests addressing dynamic monocular and binocular functions which may closely associate with the extent of myelination along visual pathways. These include Object From Motion (OFM) extraction and Time-constrained stereo protocols. In the OFM test, an array of dots compose an object, by moving the dots within the image rightward while moving the dots outside the image leftward or vice versa. The dot pattern generates a camouflaged object that cannot be detected when the dots are stationary or moving as a whole. Importantly, object recognition is critically dependent on motion perception. In the Time-constrained Stereo protocol, spatially disparate images are presented for a limited length of time, challenging binocular 3-dimensional integration in time. Both tests are appropriate for clinical usage and provide a simple, yet powerful, way to identify and quantify processes of demyelination and remyelination along visual pathways. These protocols may be efficient to diagnose and follow optic neuritis and multiple sclerosis patients.
In the diagnostic process, these protocols may reveal visual deficits that cannot be identified via current standard visual measurements. Moreover, these protocols sensitively identify the basis of the currently unexplained continued visual complaints of patients following recovery of visual acuity. In the longitudinal follow up course, the protocols can be used as a sensitive marker of demyelinating and remyelinating processes along time. These protocols may therefore be used to evaluate the efficacy of current and evolving therapeutic strategies, targeting myelination of the CNS.

Object From Motion (OFM) and Time-constrained stereo protocols are sensitive tools to identify monocular and binocular dynamic visual function deficits, which are uniquely affected in optic neuritis patients. Furthermore, these tests may be used as quantitative noninvasive tools to assess the extent of myelination along visual pathways.

Dynamische Visuelle Tests zur Identifizierung und Quantifizierung von Visual Schäden und Reparaturen Nach Demyelinisierung in Optikusneuritis Patienten

In order to follow optic neuritis patients and evaluate the effectiveness of their treatment, a handy, accurate and quantifiable tool is required to ...

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Stroke affecting white matter accounts for up to 25% of clinical stroke presentations, occurs silently at rates that may be 5-10 fold greater, and contributes significantly to the development of vascular dementia. Few models of focal white matter stroke exist and this lack of appropriate models has hampered understanding of the neurobiologic mechanisms involved in injury response and repair after this type of stroke. The main limitation of other subcortical stroke models is that they do not focally restrict the infarct to the white matter or have primarily been validated in non-murine species. This limits the ability to apply the wide variety of murine research tools to study the neurobiology of white matter stroke. Here we present a methodology for the reliable production of a focal stroke in murine white matter using a local injection of an irreversible eNOS inhibitor. We also present several variations on the general protocol including two unique stereotactic variations, retrograde neuronal tracing, as well as fresh tissue labeling and dissection that greatly expand the potential applications of this technique. These variations allow for multiple approaches to analyze the neurobiologic effects of this common and understudied form of stroke.

Here we present methodology for the production of a focal stroke in murine white matter by local injection of an irreversible endothelial nitric oxide synthase (eNOS) inhibitor (L-Nio). Presented are two stereotactic variations, retrograde neuronal tracing, and fresh tissue labeling and dissection that expand the potential applications of this technique.

Ein vielseitiges Mausmodell von Subcortical Weiß Matter Stroke für das Studium der axonalen Degeneration and White Matter Neurobiologie

Stroke affecting white matter accounts for up to 25% of clinical stroke presentations, occurs silently at rates that may be 5-10 fold greater, and ...

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

In recent years, regenerative techniques have been increasingly studied and used to treat osteochondral lesions of the talus. In particular, several studies have focused their attention on mesenchymal stem cells derived from adipose tissue. Adipose-derived stem cells (ADSCs) exhibit morphological characteristics and properties similar to other mesenchymal cells, and are able to differentiate into several cellular lines. Moreover, these cells are also widely available in the subcutaneous tissue, representing 10 - 30% of the normal body weight, with a concentration of 5,000 cells per gram of tissue.
In the presented technique, the first step involves harvesting ADSCs from the abdomen and a process of microfracture and purification; next, the surgical procedure is performed entirely arthroscopically, with less soft tissue dissection, better joint visualization, and a faster recovery compared with standard open procedures. Arthroscopy is characterized by a first phase in which the lesion is identified, isolated, and prepared with microperforations; the second step, performed dry, involves injection of adipose tissue at the level of the lesion.
Between January 2016 and September 2016, four patients underwent arthroscopic treatment of osteochondral lesion of the talus with microfractured and purified adipose tissue. All patients reported clinical improvement six months after surgery with no reported complications. Functional scores at the latest follow-up are encouraging and confirm that the technique provides reliable pain relief and improvements in patients with osteochondral lesion of the talus.

The aim of this study is to report a protocol for the arthroscopic treatment of osteochondral lesions of the talus using microfractured and purified adipose-derived stem cells.

Autologe Microfractured und gereinigtes Fettgewebe für arthroskopische Management osteochondrale Läsionen des Talus

In recent years, regenerative techniques have been increasingly studied and used to treat osteochondral lesions of the talus. In particular, several ...

Assessment of Static Graviceptive Perception in the Roll-Plane using the Subjective Visual Vertical Paradigm

Vestibular disorders are among the most common syndromes in medicine. In recent years, new vestibular diagnostic systems have been introduced that allow the examination of all semicircular canals in the clinical setting. Assessment methods of the otolithic system, which is responsible for the perception of linear acceleration and perception of gravity, are far less in clinical use. There are several experimental approaches for measuring the perception of gravity. The most frequently used method is the determination of the subjective visual vertical. This is usually measured with the head in an upright position. We present here an assessment method for testing otolith function in the roll plane. The subjective visual vertical is measured in the head upright position as well as with head inclination of &#177; 15&#176; and &#177; 30&#176; in the roll plane. This extended functional paradigm is an easy-to-perform clinical test of otolith function and ensures increased information content for the detection of impaired graviceptive perception.

The perception of gravity is commonly determined by the subjective visual vertical in the head upright position. The additional assessment at head tilts of &#177; 15&#176; and &#177; 30&#176; in the roll plane ensures increased information content for the detection of impaired graviceptive perception.

Bewertung der statischen Gravizeptiven Wahrnehmung in der Rollebene mit dem subjektiven visuellen vertikalen Paradigma

Vestibular disorders are among the most common syndromes in medicine. In recent years, new vestibular diagnostic systems have been introduced that allow ...