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JoVE Journal

Behavior

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A New Method for Inducing a Depression-Like Behavior in Rats

20.5K Views

07:57 min

February 22nd, 2018

February 22nd, 2018

20,455 Views

0:04

Title

0:40

Measuring Depression at Baseline

2:31

Induction of Depression in Rats

4:03

Establishing Depression-contagion in Naïve Rats

4:37

Open Field Test

5:08

Forced-swim Test

5:50

Results: Sucrose Preference, Open Field and Forced Swim Test Performance after Induction of Depression-like Behavior

7:22

Conclusion

Transkript

The overall goal of this model is to establish depression contagion in rats. This method can help answer key questions in the behavioral field such as mechanism of action, prevention, containment, and treatment of contagious depression. The main a

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This protocol describes a new model by which healthy rats could contract depression over a given time periodthrough contagion by exposure to chronic unpredictable stressed (CUS) rats.

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