Chapter 8
Nonlinear Pharmacokinetics
Farmacocinética no lineal: Visión general
Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...
Farmacocinética no lineal: causas de la no linealidad
Various factors contribute to nonlinearity in drug pharmacokinetics.
Nonlinearity in drug absorption may result from rate-limited solubility, ...
Farmacocinética no lineal: Ecuación de Michaelis-Menten
The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism.
It determines the rate of decline of drug concentration over time, ...
Determinación de la tasa de eliminación constante y máxima de Michaelis
The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration.
...
Farmacocinética no lineal: eliminación de fármacos para la inyección en bolo intravenoso
In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM.
Following an IV bolus, Dt, the amount of drug in the body at any ...
Distribución de fármacos como modelo de un compartimento y eliminación mediante farmacocinética no lineal: descripción general
Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes.
The metabolism of drugs ...
Parámetros que afectan a la eliminación no lineal: entrada de orden cero, absorción de primer orden y modelo de dos compartimentos
Drugs administered through different administration routes follow nonlinear elimination.
Consider a drug administered through a constant IV infusion, ...
Farmacocinética no lineal: dependencia de la vida media de eliminación y el aclaramiento de dosis
Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics.
The elimination half-life is influenced by the ...
Cronofarmacocinética: ritmos circadianos e influencia en la respuesta a fármacos
Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions.
Standard circadian ...
Cronofarmacocinética: Farmacocinética dependiente del tiempo
Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical.
Cyclic changes occur over constant ...
Farmacocinética no lineal: biodisponibilidad y unión proteína-fármaco
For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate.
A saturable pathway ...
Farmacocinética no lineal: papel de los transportadores
Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution.
These cellular transporters in cells modulate ...
ACERCA DE JoVE
Copyright © 2025 MyJoVE Corporation. Todos los derechos reservados