Chapter 8
Nonlinear Pharmacokinetics
Farmacocinética não linear: visão geral
Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...
Farmacocinética não linear: causas da não linearidade
Various factors contribute to nonlinearity in drug pharmacokinetics.
Nonlinearity in drug absorption may result from rate-limited solubility, ...
Farmacocinética não linear: equação de Michaelis-Menten
The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism.
It determines the rate of decline of drug concentration over time, ...
Determinação da Constante de Michaelis e da Taxa Máxima de Eliminação
The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration.
...
Farmacocinética não linear: eliminação de medicamentos para injeção IV em bolus
In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM.
Following an IV bolus, Dt, the amount of drug in the body at any ...
Distribuição de medicamentos como modelo de um compartimento e eliminação por farmacocinética não linear: visão geral
Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes.
The metabolism of drugs ...
Parâmetros que afetam a eliminação não linear: entrada de ordem zero, absorção de primeira ordem e modelo de dois compartimentos
Drugs administered through different administration routes follow nonlinear elimination.
Consider a drug administered through a constant IV infusion, ...
Farmacocinética não linear: dependência da meia-vida de eliminação e depuração da dose
Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics.
The elimination half-life is influenced by the ...
Cronofarmacocinética: ritmos circadianos e influência na resposta a medicamentos
Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions.
Standard circadian ...
Cronofarmacocinética: Farmacocinética Dependente do Tempo
Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical.
Cyclic changes occur over constant ...
Farmacocinética não linear: biodisponibilidade e ligação proteína-droga
For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate.
A saturable pathway ...
Farmacocinética não linear: papel dos transportadores
Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution.
These cellular transporters in cells modulate ...
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