Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...

Various factors contribute to nonlinearity in drug pharmacokinetics. Nonlinearity in drug absorption may result from rate-limited solubility, ...

The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism. It determines the rate of decline of drug concentration over time, ...

The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration. ...

In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM. Following an IV bolus, Dt, the amount of drug in the body at any ...

Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes. The metabolism of drugs ...

Drugs administered through different administration routes follow nonlinear elimination. Consider a drug administered through a constant IV infusion, ...

Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics. The elimination half-life is influenced by the ...

Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions. Standard circadian ...

Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical. Cyclic changes occur over constant ...

For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate. A saturable pathway ...

Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution. These cellular transporters in cells modulate ...