Chapter 8

Nonlinear Pharmacokinetics

Nonlinear Pharmacokinetics: Overview
Nonlinear Pharmacokinetics: Overview
Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...
Nonlinear Pharmacokinetics: Causes of Nonlinearity
Nonlinear Pharmacokinetics: Causes of Nonlinearity
Various factors contribute to nonlinearity in drug pharmacokinetics. Nonlinearity in drug absorption may result from rate-limited solubility, ...
Nonlinear Pharmacokinetics: Michaelis-Menten Equation
Nonlinear Pharmacokinetics: Michaelis-Menten Equation
The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism. It determines the rate of decline of drug concentration over time, ...
Determination of Michaelis Constant and Maximum Elimination Rate
Determination of Michaelis Constant and Maximum Elimination Rate
The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration. ...
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM. Following an IV bolus, Dt, the amount of drug in the body at any ...
Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview
Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview
Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes. The metabolism of drugs ...
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
Drugs administered through different administration routes follow nonlinear elimination. Consider a drug administered through a constant IV infusion, ...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics. The elimination half-life is influenced by the ...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions. Standard circadian ...
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical. Cyclic changes occur over constant ...
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate. A saturable pathway ...
Nonlinear Pharmacokinetics: Role of Transporters
Nonlinear Pharmacokinetics: Role of Transporters
Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution. These cellular transporters in cells modulate ...
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