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JoVE Journal

Medicine

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An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

8.2K Views

08:48 min

June 30th, 2015

June 30th, 2015

8,155 Views

0:05

Title

1:36

Clonogenic Assay Plate Preparation

4:13

Clonogenic Assay

6:34

Results: Pi3 Kinase Inhibitors Activate the Doormant Phenotype in Estrogen Sensitive Cells

7:59

Conclusion

We developed an in vitro model of dormancy in the bone marrow for estrogen-sensitive breast cancer cells. The goal of this protocol is to demonstrate use of the model for the study of the molecular and cellular biology of dormancy and for generation of hypotheses for subsequent testing in vivo.

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