Department of Chemistry
Dr. Chen received her Ph.D. in Molecular Cell & Developmental Biology from University of Texas at Austin. She was a postdoctoral fellow at Stanford University School of Medicine. Dr. Chen started her own independent research as a tenure track assistant professor at Johns Hopkins University in 2008 and is a full professor now. Dr. Chen’s laboratory investigates epigenetic regulation in various stem cell lineages during animal development, using model organisms Drosophila, C. elegans and mice.
The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) production.
The Journal of biological chemistry Feb, 2015 | Pubmed ID: 25583990
Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes.
Nature genetics Oct, 2015 | Pubmed ID: 26301496
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
The EMBO journal Dec, 2015 | Pubmed ID: 26492917
Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2016 | Pubmed ID: 26862168
Outcomes of cataract surgery with residents as primary surgeons in the Veterans Affairs Healthcare System.
Journal of cataract and refractive surgery Mar, 2016 | Pubmed ID: 27063517
Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.
Gastroenterology 10, 2017 | Pubmed ID: 28625833
SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation.
Diabetes 01, 2018 | Pubmed ID: 28851713
Genome-wide identification and differential analysis of translational initiation.
Nature communications 11, 2017 | Pubmed ID: 29170441
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
The Journal of clinical investigation 04, 2018 | Pubmed ID: 29480818
Rapid inhibition of atherosclerotic plaque progression by sonodynamic therapy.
Cardiovascular research 01, 2019 | Pubmed ID: 29878150
miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity.
Diabetes 12, 2018 | Pubmed ID: 30002134
Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer.
Cell reports 08, 2018 | Pubmed ID: 30089255
miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution.
Stem cells (Dayton, Ohio) 12, 2018 | Pubmed ID: 30267595
Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution.
Antioxidants & redox signaling 06, 2019 | Pubmed ID: 30358421
Is a Tumor Suppressor Gene in Colorectal Cancer.
Molecular cancer research : MCR 03, 2019 | Pubmed ID: 30606770
Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.
Nature cell biology 03, 2019 | Pubmed ID: 30778220
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc.
Nature immunology 07, 2019 | Pubmed ID: 31086333
PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity.
The EMBO journal 07, 2019 | Pubmed ID: 31304624
Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines.
Genome medicine 08, 2019 | Pubmed ID: 31446897
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.
Cell Oct, 2019 | Pubmed ID: 31675502
The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis.
Nucleic acids research 03, 2020 | Pubmed ID: 31863590
12-h clock regulation of genetic information flow by XBP1s.
PLoS biology 01, 2020 | Pubmed ID: 31935211
Proteogenomic Characterization of Endometrial Carcinoma.
Cell Feb, 2020 | Pubmed ID: 32059776
Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer.
Cancer cell Mar, 2020 | Pubmed ID: 32142667
Psoriasis Vulgaris of Blood Heat Syndrome in Plasma Based on Widely Targeted Techniques.
Journal of healthcare engineering , 2022 | Pubmed ID: 35463691
Traditional Chinese medicine auricular point acupressure for the relief of pain, fatigue, and gastrointestinal adverse reactions after the injection of novel coronavirus-19 vaccines: a structured summary of a study protocol for a multicentre, three-arm, single-blind, prospective randomized controlled trial.
Trials Feb, 2021 | Pubmed ID: 33632286
Auricular acupressure for adverse events following immunization related to COVID-19 vaccine injection: study protocol for a multicenter, three-arm, blinded randomized controlled trial.
Trials Nov, 2021 | Pubmed ID: 34838110
Continuous theta burst stimulation over left and right supramarginal gyri demonstrates their involvement in auditory feedback control of vocal production.
Cerebral cortex (New York, N.Y. : 1991) Dec, 2022 | Pubmed ID: 35174862
MRI Fat-Saturated T2-Weighted Radiomics Model for Identifying the Ki-67 Index of Soft Tissue Sarcomas.
Journal of magnetic resonance imaging : JMRI Aug, 2023 | Pubmed ID: 36326136
Auricular acupressure for adverse events following immunization after COVID-19 vaccine injection: A multicentre, blinded, randomized controlled trial.
Complementary therapies in medicine Dec, 2022 | Pubmed ID: 36372315
The relationship between sublingual immunotherapy for allergic rhinitis and the risk of symptoms in patients with COVID-19 infection.
Human vaccines & immunotherapeutics Aug, 2023 | Pubmed ID: 37530139
Intratumoral and peritumoral MRI-based radiomics prediction of histopathological grade in soft tissue sarcomas: a two-center study.
Cancer imaging : the official publication of the International Cancer Imaging Society Oct, 2023 | Pubmed ID: 37885031
Prenatal heavy metal exposure and pediatric asthma, allergic rhinitis, atopic dermatitis: a systematic review and meta-analysis.
Expert review of clinical immunology Nov, 2024 | Pubmed ID: 39109589
Intranasal insulin for the treatment of olfactory dysfunction: a protocol for a systematic review and meta-analysis.
BMJ open Nov, 2024 | Pubmed ID: 39532357
1Chongqing Clinical Research Center for Dermatology, Chongqing Key Laboratory of Integrative Dermatology Research, Key Laboratory of External Therapies of Traditional Chinese Medicine in Eczema, Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine,
2General Surgery, Chongqing Hospital of Traditional Chinese Medicine
Jipei He*,1,2,
Heng Li*,1,
Xiaojiang Dai1,
Zhengyong Xie2,
Zhigao Song3,
Xi Chen2,
Hongyan Huang1,
Yunfa Ding1,
Tengfei Qi1,
Qing Liu4,
Hongbin Zhang2,5,
Liangping Wu1,6
1, Jinshazhou Hospital of Guangzhou University of Chinese Medicine,
2, General Hospital of Southern Theatre Command,
3Department of Cardiovascular Surgery, Zhujiang Hospital of Southern Medical University,
4Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
5School of Laboratory and Biotechnology, Southern Medical University,
6, Guangzhou Hualiang Qingying Biotechnology Co. Ltd
Yu Li1,
Fengjiao Zhou2,
Hui Zhang1,
Xi Chen1,
Man Yin1,
Mi Tang1,
Jianfeng Zhang3,
Zeyi Lv1,
Hao Yang1,
Yue Huang1,
XinRong Li1
1Integrated Chinese and Western Medicine Ear, Nose, Throat, Head, and Neck Surgery, Hospital of Chengdu University of Traditional Chinese Medicine,
2Hospital of Chengdu University of Traditional Chinese Medicine, Hospital of Chengdu University of Traditional Chinese Medicine,
3, Chongqing Jiangjin District Hospital of Traditional Chinese Medicine