Enumeration of C. difficile from Mouse Fecal Content
5:03
Results: The Murine Model of C. difficile Infection Demonstrates Significant Weight Loss, Bacterial Colonization and Histopathological Changes in Infected Mice
6:10
Conclusion
Transcription
The overall goal of this protocol is to provide a step by step guide for implementing the cefoperazone mouse model of Clostridium difficile infection, with special emphasis on clinical disease monitoring, bacteria enumeration, toxin cytotoxicity,
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This protocol outlines the cefoperazone mouse model of Clostridium difficile infection (CDI) using a clinically-relevant and genetically-tractable strain, R20291. Emphasis on clinical disease monitoring, C. difficile bacterial enumeration, toxin cytotoxicity, and histopathological changes throughout CDI in a mouse model are detailed in the protocol.