Results: Toxicological Assessment of Changes in the Intracellular EGSH as Measured by roGFP2
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Conclusion
Transcription
The overall goal of this methodology is to establish the use of genetically-encoded redox sensors for the specific assessment of toxicant-induced perturbations in redox homeostasis. By overcoming the significant limitations of conventional approac
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This manuscript describes the use of genetically-encoded fluorogenic reporters in an application of live-cell imaging for the examination of xenobiotic-induced oxidative stress. This experimental approach offers unparalleled spatiotemporal resolution, sensitivity, and specificity while avoiding many of the shortcomings of conventional methods used for the detection of toxicological oxidative stress.