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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

DOI :

10.3791/58306-v

October 13th, 2018

October 13th, 2018

11,486 Views

1Department of Psychology, University of California, Los Angeles, 2Staglin Center for Brain and Behavioral Health, University of California, Los Angeles, 3Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles

Here we describe the detailed methodology required to conduct stress-enhanced fear learning (SEFL) experiments, a preclinical model of post-traumatic stress disorder, in both rats and mice. The model utilizes aspects of Pavlovian fear conditioning and freezing as an index of enhanced fear in rodents.

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