L-Dopamine (L-DOPA) Chronic Treatment and Abnormal Involuntary Movements (AIMs) Recording and Scoring
5:27
Results: The AIMs Patterns in Unilaterally 6-OHDA-Lesioned Rats Chronically Treated with L-DOPA for 3 Weeks
6:16
Conclusion
Transcription
Rating L-DOPA-induced dyskinesias in the 6-hydroxydopamine rat model of the Parkinson's disease is an important preclinical tool to identify effective antidyskinetic interventions. This model is relatively simple, presents low cost, and has simila
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Rodent models of L-DOPA-induced dyskinesias are invaluable tools to identify therapeutic interventions to attenuate the development or alleviate the manifestations that emerge due to the repeated administration of L-DOPA. This protocol demonstrates how to induce and analyze dyskinetic-like movements in the unilaterally 6-OHDA-lesioned rat model of Parkinson's disease.