Internal Carotid Injection and Post-Injection Recovery
7:44
Results: Generation of Brain Metastasis Murine Model for Screening and Evaluating the Therapeutic Profile of Drugs
9:23
Conclusion
Transcription
So why is this protocol significant? Well, brain metastases is very challenging to treat and this protocol produces a clinically-relevant mouse model with minimal extracranial tumors. This technique allows objective analysis of drug distribution a
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Brain metastasis is a cause of severe morbidity and mortality in cancer patients. Most brain metastasis mouse models are complicated by systemic metastases confounding analysis of mortality and therapeutic intervention outcomes. Presented here is a protocol for internal carotid injection of cancer cells that produces consistent intracranial tumors with minimal systemic tumors.