Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

6.0K Views

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10:01 min

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August 2nd, 2022

DOI :

10.3791/64216-v

August 2nd, 2022

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Malcolm Lim¹, Nicholas Fletcher², Amy McCart Reed¹, Melanie Flint³, Kristofer Thurecht², Jodi Saunus*¹^,⁴, Sunil R. Lakhani*¹^,⁵

¹UQ Centre for Clinical Research, The University of Queensland, ²Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, ³School of Biomedical Sciences, The University of Queensland, ⁴Mater Research and Mater Research Institute, The University of Queensland, ⁵Pathology Queensland, Royal Brisbane Women's Hospital

Summary

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Brain Metastasis

Internal Carotid Artery Injection

Dissection Microscope

Chapters in this video

0:04

Introduction

1:06

Preparation of Cancer Cells for Injection

3:01

Preparation of the Mouse for the Procedure

4:06

Internal Carotid Injection and Post-Injection Recovery

7:44

Results: Generation of Brain Metastasis Murine Model for Screening and Evaluating the Therapeutic Profile of Drugs

9:23

Conclusion

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