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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

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10:20 min

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November 11th, 2016

DOI :

10.3791/54540-v

November 11th, 2016

•

8,402 Views

Ye Han*¹, Kyle A. Lyman*¹, Matt Clutter², Gary E. Schiltz³, Quratul-Ain Ismail¹, Xiangying Cheng¹, Chi-Hao Luan⁴, Dane M. Chetkovich¹^,⁵

¹Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, ²Center for Molecular Innovation and Drug Discovery, Northwestern University, ³Department of Pharmacology, Feinberg School of Medicine, Northwestern University, ⁴High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, ⁵Department of Physiology, Feinberg School of Medicine, Northwestern University

章

文字起こし

要約

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Small Molecule Inhibitors

Protein protein Interaction

HCN1

TRIP8b

High throughput Screening

Fluorescence Polarization

Inhibition Assay

Depression

Therapeutic Target

Acoustic Liquid Handler

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