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Laser Microdissection-Based Protocol for the LC-MS/MS Analysis of the Proteomic Profile of Neuromelanin Granules

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07:35 min

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December 16th, 2021

DOI :

10.3791/63289-v

December 16th, 2021

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2,063 Views

Maximilian Wulf¹^,², Katalin Barkovits-Boeddinghaus¹^,², Paula Sommer¹^,², Karin Schork¹^,², Martin Eisenacher¹^,², Peter Riederer³^,⁴, Manfred Gerlach⁵, Steffen Kösters¹^,², Britta Eggers*¹^,², Katrin Marcus*¹^,²

¹Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum, ²Medical Proteome Analysis, Center for Proteindiagnostics (PRODI), Ruhr-University Bochum, ³Center of Mental Health; Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, ⁴Psychiatry Department of Clinical Research, University of Southern Denmark Odense University Hospital, ⁵Center of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, University of Wuerzburg

章

文字起こし

要約

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Laser Microdissection

Proteomic Profile

Neuromelanin Granules

Mass Spectrometry

Postmortem Brain Tissue

Proteomic Analysis

Disease Mechanisms

Tissue Membrane Slide

Robo Stage

Field Of View Analysis

Proteomic Raw Data Analysis

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