FD was supported by a Young Investigator Award from the National Alliance for Research on Schizophrenia and Depression and a CPRF Award from the Canadian Psychiatric Research Foundation.

1. Experimental Design, Methodological Issues, &amp; Stimuli
The SMP consist of two tasks, an encoding task and a retrieval task, and recording of brain activity may occur during the encoding task or during 
both encoding and retrieval tasks (see Figure 1 for a diagram illustrating the design of the SMP).
<img src="/files/ftp_upload/2433/2433fig1.jpg" alt="Figure 1" /> 
Figure 1. General Diagram of the SMP design. Brain regions whose activity dur...

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No conflicts of interest declared.

This experimental protocol allows investigation of the neural correlates of the memory-enhancing effect of emotion, by specifically separating 
the memory-related brain activity that is susceptible to modulation by emotion from activity in brain regions susceptible to emotion modulation during 
general/perceptual processing. This design has been instrumental in advancing our understanding of the neural mechanisms underlying the impact of emotion on 
memory, and given its versatility it is expected that SMP will remain cr...

brain imaging investigation of the memory-enhancing effect of emotion

Emotional events tend to be better remembered than non-emotional events1,2. One goal of cognitive and affective neuroscientists is 
to understand the neural mechanisms underlying this enhancing effect of emotion on memory. A method that has proven particularly influential in the 
investigation of the memory-enhancing effect of emotion is the so-called subsequent memory paradigm (SMP). This method was originally used to investigate the 
neural correlates of non-emotional memories3, and more recently we and others also applied it successfully to studies of emotional memory (reviewed in4, 5-7). 
Here, we describe a protocol that allows investigation of the neural correlates of the memory-enhancing effect of emotion using the SMP in conjunction with 
event-related functional magnetic resonance imaging (fMRI). An important feature of the SMP is that it allows separation of brain activity specifically 
associated with memory from more general activity associated with perception. Moreover, in the context of investigating the impact of emotional stimuli, 
SMP allows identification of brain regions whose activity is susceptible to emotional modulation of both general/perceptual and memory-specific processing. 
This protocol can be used in healthy subjects8-15, as well as in clinical patients where there are alterations in the neural correlates of emotion perception 
and biases in remembering emotional events, such as those suffering from depression and post-traumatic stress disorder (PTSD)16, 17.

Watch this Scientific Journal Video about Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion at JoVE.com

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

We present a protocol that uses functional magnetic resonance imaging to investigate the neural correlates of the memory-enhancing effect of emotion. This protocol allows identification of brain activity specifically linked to memory-related processing, contrary to more general perceptual processing, and can be used with healthy and clinical populations.

Emotional events tend to be better remembered than non-emotional events1,2. One goal of cognitive and affective neuroscientists is 
to understand the ...

brain-imaging-investigation-of-the-memory-enhancing-effect-of-emotion

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16.1K 조회수.  University of Alberta. 우리는 감정의 메모리 향상 효과의 신경 상호 조사를 기능성 자기 공명 이미징을 사용하는 프로토콜을 제시한다. 이 프로토콜은 뇌 활동의 식별은 특별히 좀 더 일반적인 지각 처리에 반하는 메모리 관련 처리에 연결할 수 있으며, 건강하고 임상 인구와 함께 사용할 수 있습니다.