Results: Host CX3CR1+ Macrophages Communicate with Donor OT-II Cells During OVA-driven Transfer Colitis
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Conclusion
필기록
The overall goal of this antigen-driven colitis model is to determine whether CX3, CR1 positive mononuclear phagocytes interact with and activate CD4 positive T cells during antigen-specific colitis and whether this mononuclear phagocyte-dependent
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In this antigen-driven colitis model, OT-II CD4+ T cells expressing a red fluorescent protein were adoptively transferred into RAG-/- mice that express a green fluorescent protein in mononuclear phagocytes (MPs). The hosts were challenged with Escherichia coli (E.coli) expressing the ovalbumin protein (OVA) fused to a cyan fluorescent protein (CFP).