February 10th, 2023
•This protocol describes the orthotopic implantation of patient-derived cancer cells in the cecum wall of immunodeficient mice. The model recapitulates advanced colorectal cancer metastatic disease and allows for the evaluation of new therapeutic drugs in a clinically relevant scenario of lung and liver metastases.
Tags
Related Videos
Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
Orthotopic Injection of Breast Cancer Cells into the Mice Mammary Fat Pad
Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids
Translational Orthotopic Models of Glioblastoma Multiforme
Copyright © 2024 MyJoVE Corporation. 판권 소유