JoVE Journal

Cancer Research

Author Produced

Aby wyświetlić tę treść, wymagana jest subskrypcja JoVE.

live

MEDIA_ELEMENT_ERROR: Format error

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Please note that all translations are automatically generated. Click here for the English version.

8.8K Views

•

05:36 min

•

February 8th, 2020

DOI :

10.3791/60314-v

February 8th, 2020

•

Moe Ishihara*¹, Junhui Hu*¹, Xiaoyu Zhang², YongHyeon Choi³, Anthony Wong⁴, Celine Cano-Ruiz⁵, Rongwei Zhao⁶, Ping Tan⁷, Jonathan L. Tso¹, Lily Wu¹^,⁸

¹Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, ²Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, ³Department of Bioengineering, Hanyang University, ⁴Department of Ecology and Evolutionary Biology, University of California, Los Angeles, ⁵Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, ⁶School of Life Sciences, Beijing Normal University, ⁷Department of Urology, West China Hospital, Sichuan University, ⁸Department of Urology, David Geffen School of Medicine, University of California, Los Angeles

Podsumowanie

Metastatic clear cell renal cell carcinoma is a disease without a comprehensive animal model for thorough preclinical investigation. This protocol illustrates two novel animal models for the disease: the orthotopically implanted mouse model and the chicken chorioallantoic membrane model, both of which demonstrate lung metastasis resembling clinical cases.

Przeglądaj więcej filmów

Metastatic Clear Cell Renal Cell Carcinoma

Chicken Chorioallantoic Membrane Model

Molecular Mechanism

Implantation Protocol

Circulating Tumor Cells

Surgical Procedure

Rozdziały w tym wideo

0:00

Introduction

2:03

Orthotopic Implantation

4:01

Results

5:03

Conclusion

Powiązane Filmy

article

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

10.5K Views

article

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

13.4K Views

article

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

9.6K Views

article

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

7.4K Views

article

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

9.7K Views

article

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array (HMCA)-based Plates

9.0K Views

article

Time-Lapse 2D Imaging of Phagocytic Activity in M1 Macrophage-4T1 Mouse Mammary Carcinoma Cells in Co-cultures

9.0K Views

article

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

10.1K Views

article

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

6.7K Views

article

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

2.5K Views

Copyright © 2025 MyJoVE Corporation. Wszelkie prawa zastrzeżone

Używamy plików cookie, aby ulepszyć Twoje wrażenia z korzystania z naszej witryny.

Kontynuując korzystanie z naszej witryny lub klikając „Kontynuuj”, wyrażasz zgodę na akceptację naszych plików cookie.

Dowiedz się więcej