Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

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276 Views

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09:48 min

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August 23rd, 2024

DOI :

10.3791/66961-v

August 23rd, 2024

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Alan Halim¹, Sujan Kumar Mondal¹^,², Nasreen Al-Qadi¹, Elizabeth Kenyon¹^,², Keith MacRenaris³^,⁵, Thomas V. O’Halloran⁴^,⁵, Zdravka Medarova⁶, Anna Moore¹^,²

¹Precision Health Program, Michigan State University, ²Department of Radiology, College of Human Medicine, Michigan State University, ³Department of Microbiology, Genetics, & Immunology, College of Natural Science, Michigan State University, ⁴Department of Chemistry, College of Natural Science, Michigan State University, ⁵Elemental Health Institute, Michigan State University, ⁶Transcode Therapeutics Inc.

Podsumowanie

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Nanodrug Accumulation

Murine Breast Cancer

Metastatic Breast Cancer

Therapeutic Strategies

Oncogenic MiRNAs

RNA Delivery

Iron Oxide Nanoparticles

Magnetic Resonance Imaging

Vascular Permeability

Therapeutic Oligomers

Cy5 5 Dye

Fluorescence Microscopy

Metastatic Sites

Rozdziały w tym wideo

0:00

Introduction

1:15

Induction of Orthotopic Tumors in Mice Using MDA-MB-231 Luciferase Expressing Cells

3:32

Monitoring Tumor Growth and Metastasis Development in Mice with Bioluminescence Imaging (BLI)

5:04

Delivery of Magnetic Iron Oxide Nanoparticles Carrying RNA Oligomers to Metastatic Breast Cancer Mouse Model

6:32

Collection of Metastases from Metastatic Breast Cancer Mouse Model for Analysis and Validation of Nanodrug Delivery by Fluorescence Microscopy

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