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Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

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10:26 min

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January 16th, 2015

January 16th, 2015

•
8,359 Views

0:05

Title

1:22

Immature Mosquito Development and Survivorship Assays

3:17

Fecundity Assay by Administering Drug Through Artifitial Feeder to Female Mosquitoes

5:56

Biochemical Assay of Mosquito Enzyme Inhibition by Drug

8:25

Results: Effect of DZNep on Malaria Mosquitoes

10:00

Concluision

A protocol is developed to examine the effects of an epigenetic drug DZNep on the development, fecundity and survivorship of mosquitoes. Here we describe procedures for the aqueous exposure of DZNep to immature mosquitoes and a blood-based exposure of DZNep to adult mosquitoes in addition to measuring SAH hydrolase inhibition.

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