Bone Morphogenetic Protein-2 (rhBMP-2)-Soaked Sponge Scaffold and Surgical Preparation
1:54
Segmental Femoral Defect Induction
5:50
Results: Representative Segmental Femoral Defect Bone Recovery Analyses
7:21
Conclusion
TRANSCRIÇÃO
This surgical protocol uses a consistent and reproducible externally fixed segmental defect model to evaluate the healing mechanisms of bone and the use of potential regenerative therapies. We have streamlined a challenging surgery for the creatio
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In vivo mammalian models of critical-sized bone defects are essential for researchers studying healing mechanisms and orthopedic therapies. Here, we introduce a protocol for the creation of reproducible, segmental, femoral defects in rats stabilized using external fixation.