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JoVE Journal

Medicine

This content is Open Access.

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

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09:15 min

January 12th, 2020

January 12th, 2020

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0:04

Title

0:42

Experimental Setup and Purified Experimental Diet Acclimatization

1:21

Vinyl Chloride (VC) Inhalation Exposure System Setup

2:17

Pre-Exposure Setup

3:21

Exposure Experiment and VC Concentration Validation

6:12

Post-Exposure

7:01

Results: Representative Effects of VC on the Enhancement of Diet-Induced Liver Injury

8:29

Conclusion

Transcrição

The goal of this protocol was to develop a murine model of low-level toxicant exposure that does not cause overt liver injury but rather exacerbates pre-existing liver damage. This paradigm better recapitulates human exposure and the subtle changes that occur upon exposure to toxicant concentrations that are considered safe.

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