Testing Responses to Genomically Identified Targets in PDX Models
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Representative Results
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Conclusion
TRANSCRIÇÃO
The protocol described here is aimed to demonstrate an algorithm for testing treatment efficacy using in vivo cancer models. The protocol consists of a combination of several techniques. Whole genome bio-sequencing of human tumor specimens is used
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Here we present a protocol to test the efficacy of targeted therapies selected based on the genomic makeup of a tumor. The protocol describes identification and validation of structural DNA rearrangements, engraftment of patients’ tumors into mice and testing responses to corresponding drugs.