Желчного протока Лигирование у мышей Индукция воспалительного печени травматизма и фиброза обструктивной холестаза

Disruption of bile flow results in severe inflammatory cholestatic liver injury with a characteristic time-dependent sequence of morphological alterations. Here we present a protocol for the surgical ligation of the common bile duct in mice that allows to induce a strong fibrotic response after 21 to 28 days.