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Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

DOI :

10.3791/3716-v

9:23 min

July 29th, 2012

July 29th, 2012

13,411 Views

1Chagas Disease Multidisciplinary Research Laboratory, University of Brasilia

The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.

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Parasite induced

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