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Forebrain Electrophysiological Recording in Larval Zebrafish

DOI :

10.3791/50104-v

January 24th, 2013

January 24th, 2013

16,430 Views

1Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco

A simple method to record extracellular field potentials in the larval zebrafish forebrain is described. The method provides a robust in vivo read-out of seizure-like activity. This technique can be used with genetically modified zebrafish larvae carrying epilepsy-related genes or seizures evoked by administration of convulsant drugs.

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