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Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases

DOI :

10.3791/50957-v

10:59 min

November 18th, 2013

November 18th, 2013

17,631 Views

1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi

Recent development in gene targeting tools makes production of knockout (KO) rabbits possible. In the present work, we generated five Apolipoprotein (Apo) C-III KO rabbits using Zinc Finger Nucleases (ZFN). This work demonstrated that ZFN is a highly efficient method to produce KO rabbits.

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Apolipoprotein C III

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