JoVE Logo
Faculty Resource Center

Sign In

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

DOI :

10.3791/51485-v

April 29th, 2014

April 29th, 2014

16,173 Views

1Genitourinary Section, Department of Medicine, Roswell Park Cancer Institute, 2Biological Sciences Platform, Sunnybrook Research Institute

Models of spontaneous metastatic renal cell carcinoma (RCC) disease progression can be used for evaluating treatments in a clinically relevant setting. This protocol demonstrates different procedures for orthotopic kidney tumor cell implantation, proper nephrectomy, and finally outlines a necropsy guide for visual and bioluminescent scoring of metastatic burden and localization.

Tags

Metastatic Renal Cell Carcinoma

-- Views

Related Videos

article

Single Port Donor Nephrectomy

article

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

article

Mammary Transplantation of Stromal Cells and Carcinoma Cells in C57BL/6J Mice

article

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

article

Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase

article

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

article

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

article

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

article

Modeling Chemotherapy Resistant Leukemia In Vitro

article

Assessment of Kidney Function in Mouse Models of Glomerular Disease

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved