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Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa

DOI :

10.3791/54115-v

11:31 min

June 30th, 2016

June 30th, 2016

7,976 Views

1Division of Molecular Microbiology, College of Life Sciences, University of Dundee

This article describes the high-throughput assay that has been successfully established to screen large libraries of small molecules for their potential ability to manipulate cellular levels of cyclic di-GMP in Pseudomonas aeruginosa, providing a new powerful tool for antibacterial drug discovery and compound testing.

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High throughput Setup

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