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A Novel Method to Model Chronic Traumatic Encephalopathy in Drosophila

DOI :

10.3791/55602-v

July 4th, 2017

July 4th, 2017

7,917 Views

1Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine

Here, we describe a new approach to inflict closed-head traumatic brain injury in Drosophila melanogaster. Our method has the advantage of directly delivering repetitive impacts with adjustable strength to the head alone. Further exploration of the invertebrate system will help to illuminate the pathogenesis of chronic traumatic encephalopathy.

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Chronic Traumatic Encephalopathy

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