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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

DOI :

10.3791/56464-v

November 26th, 2017

November 26th, 2017

8,302 Views

1Protein Aggregation and Aging, German Center for Neurodegenerative Diseases (DZNE), 2Graduate School of Cellular and Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE)

The goal of the method presented here is to explore protein aggregation during normal aging in the model organism C. elegans. The protocol represents a powerful tool to study the highly insoluble large aggregates that form with age and to determine how changes in proteostasis impact protein aggregation.

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