Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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06:40 min
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January 25th, 2018
DOI :
January 25th, 2018
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Chapters in this video
0:05
Title
1:17
Measurement of Luciferase Reporter Signals, which Correspond to γ-Secretase Cleavage of APP-C99 (CG cells) or NΔE (NG cells)
3:42
Quantification of γ-Secretase Activity
4:40
Results: Treatments with CL-387, 785 can Differentially Promote the Processing of APP-C99 by γ-Secretase without Affecting Notch Cleavage
6:05
Conclusion
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