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Miniaturized Sample Preparation for Transmission Electron Microscopy

DOI :

10.3791/57310-v

9:04 min

July 27th, 2018

July 27th, 2018

18,773 Views

1Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, 2Swiss Nanoscience Institute, University of Basel, 3BioEM lab, Biozentrum, University of Basel

An instrument and methods for the preparation of nanoliter-sized sample volumes for transmission electron microscopy is presented. No paper-blotting steps are required, thus avoiding the detrimental consequences this can have for proteins, significantly reducing sample loss and enabling the analysis of single cell lysate for visual proteomics.

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Keywords Miniaturized Sample Preparation

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